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This comprehensive book encompasses various facets of sterile product development. Key concepts relevant to the successful development of sterile products are illustrated through case studies and are covered under three sections in this book: • Formulation approaches that discuss a variety of dosage forms including protein therapeutics, lipid-based controlled delivery systems, PEGylated biotherapeutics, nasal dosage form, and vaccines • Process, container closure and delivery considerations including freeze-thaw process challenges, best practices for technology transfer to enable commercial product development, innovations and advancement in aseptic fill-finish operations, approaches to ...
Volume 65 contains six reviews covering key contemporary topics on crop and soil sciences. The topics are varied and exemplary of the array of subjects dealt with by this long-running serial. With this latest volume, Advances in Agronomy continues to be recognized as a leading reference and a first-rate source of the latest and best research in agronomy. - Advances in Fertigation - The Genetics, Pathology, and Molecular Biology of T-Cytoplasm Male Sterility in Maize - Application of Capillary Electrophoresis to Anion Speciation in Soil Water Extracts - Advances in Solution Culture Methods for Plant Mineral Nutrition Research - Radiation Use Efficiency - The Effects of Cultivation on Soil Nitrogen Mineralization
This revised and updated edition of Ladybirds provides a succinct but comprehensive and accessible overview of the biology of ladybirds and their parasites, focusing on ecology in an evolutionary context. It provides the latest information, coverage of recent additions to the British list including the harlequin ladybird, and makes suggestions for further research, both short and long term, highlighting gaps in knowledge and showing readers how to get involved with recording and studying ladybirds. It includes updated keys for the identification of ladybirds at late-instar larval and adult stages, and techniques for studying ladybirds and their parasites in both laboratory and field. The authors hope that this book will be a valuable resource, not only for students, from school to university and beyond, but also for anyone with an interest in natural history, whether professional or recreational.
This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development. Twenty-eight comprehensive chapters cover dosage forms, liquid and lyophilized drug products. The introductory chapters of this book define key elements of QbD and examine how these elements are integrated into drug product development. These chapters also discuss lessons learned from the FDA Office of Biotechnology Products pilot program. Following chapters demonstrate how QbD is used for formulation development ranging from screening of formulations to developability assessment to development of lyophilized and liquid formats. The next few chapters study the use of small-scale and...
With over 100 illustrations, Volume 1 addresses the core disciplines of pharmaceutics (absorption, PK, excipients, tablet dosage forms, and packaging), and explores the challenges and paradigms of pharmaceutics.Key topics in Volume 1 include: principles of drug absorption, chemical kinetics, and drug stability pharmacokinetics the effect of rout
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Filling a gap in the literature, this is the first book to focus on the fabrication of functional porous materials by using ice templating and freeze drying. Comprehensive in its scope, the volume covers such techniques as the fabrication of porous polymers, porous ceramics, biomimic strong composites, carbon nanostructured materials, nanomedicine, porous nanostructures by freeze drying of colloidal or nanoparticle suspensions, and porous materials by combining ice templating and other techniques. In addition, applications for each type of material are also discussed. Of great benefit to those working in the freeze-drying field and researchers in porous materials, materials chemistry, engineering, and the use of such materials for various applications, both in academia and industry.
This third edition expands on the previous editions with updated and new chapters on protein chromatography. Chapters detail protein stability and storage, avoiding proteolysis, protein quantitation methods, generation and purification of recombinant proteins, recombinant antibody production, and the tagging of proteins. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Chromatography: Methods and Protocols, Third Edition aims to provide commonly used methods and new approaches to help both new researchers and experts expand their knowledge.