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Solubility, Delivery and ADME Problems of Drugs and Drug Candidates
"This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability, drug-drug interaction potential and a special delivery tool of drug candidates. The book provides an integrated view of"
Transmucosal Absorption Enhancers in the Drug Delivery Field
Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
Vascular Endothelium
Proceedings of a NATO ARW held in Crete, Greece, June 22-July 1, 1996
Chronic Pain: New Insights for the Healthcare Professional: 2013 Edition
Chronic Pain: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Additional Research. The editors have built Chronic Pain: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Pain: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Elsötétítés
Berlin, 1939. december Németország háborúban áll. A nácik szorítása egyre rémisztőbb az országban. A paranoiát tovább fokozza a lakosságra kényszerített parancs, amely miatt minden éjjel kötelező a teljes elsötétítés a fővárosban. Egy nő meggyilkolása után Horst Schenke bűnügyi nyomozóra óriási nyomás nehezedik, hogy minél hamarabb megoldja az ügyet. Schenke, akit felettesei gyanakodva figyelnek, mert még mindig nem lépett be a náci pártba, borotvaélen táncol – a hűtlenség büntetése az azonnali halál. A második áldozat megtalálása megerősíti Schenke legnagyobb félelmét. Miközben a nyomozás mind közelebb viszi a rezsim gonosz szívéhez, a felügyelő rájön, hogy a náci párt egymással viaskodó frakciói ugyanolyan könyörtelenek, mint az utcákon lesben álló gyilkos...
Tallózó
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Organotypic Models in Drug Development
This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
