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Neutrophil Communication
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
NETosis 2: The Excitement Continues
NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nucle...
Zellen · Leben · Relationomische Medizin
Der Makrokosmos, den wir als Kulturwesen ständig verändern, beeinflusst auch den Mikrokosmos unserer Zellen. Dies hat Konsequenzen nicht nur für unsere Ernährung, unseren Lebensstil und die Medizin, sondern auch für den Umgang mit unserer Umwelt und den Ressourcen. Und es hat Konsequenzen für die Regeln, die wir uns als freie Menschen auferlegen, um zu überleben. Aufgrund der herausragenden Bedeutung der Relationen werden in diesem Buch drei neue Begriffe vorgeschlagen: das Relationom beziehungsweise die Relationome, die Relationom-Forschung und die Relationomische Medizin. Denn alles ist miteinander verbunden. Wir leben in Beziehung zu allem, was da draußen und in uns ist, mittelbar und unmittelbar. Deshalb ist die Betrachtung von Relationomen des Makro- und Mikrokosmos fundamental in der Relationomischen Medizin. Die Relationomische Medizin ist eine praktische Wissenschaft, bei der die Relationome in Hinblick auf ihre Bedeutung für die Prävention, Entstehung und Heilung von Krankheiten im Fokus stehen.
Proteomics Sample Preparation
This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.
