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View Inside the Barrel
Chaperonins are a unique class of molecular chaperone that assist in the folding of newly synthesized, partially folded, and misfolded proteins. The importance of these folding machines is evident by their conservation across all three branches of life. The general structure of the chaperonins consists of 14-18 subunits, which form two back-to-back cavities. Unfolded polypeptide substrate is captured in one of the two cavities, and assisted to its native conformation in an ATP dependent fashion. The chaperonins can be separated into two, related, but unique groups. The group I chaperonins, typified by GroEL from bacteria, are fairly well understood, however, there are substantial gaps in our...
MHC Class-I Loss and Cancer Immune Escape
This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”. Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answ...
Global Perspectives in Family Therapy
Global Perspectives in Family Therapy: Development,Practice, Trends provides an overview of the development of the family and the issues and concerns they are faced with in different cultural contexts. Contributions from experts in the field expand on the different aspects on the historical beginnings, current developments, training issues, theoretical variations, future trends, and research potential in family therapy throughout 14 countries. It explores the diverse cultural approach to family therapy and suggests various clinical interventions that are helpful to clinicians dealing with families from different countries, including case studies, vignettes and research outcomes of family therapy overseas.
Rethinking Urban Risk and Resettlement in the Global South
Environmental changes have significant impacts on people’s lives and livelihoods, particularly the urban poor and those living in informal settlements. In an effort to reduce urban residents’ exposure to climate change and hazards such as natural disasters, resettlement programmes are becoming widespread across the Global South. While resettlement may reduce a region’s future climate-related disaster risk, it often increases poverty and vulnerability, and can be used as a reason to evict people from areas undergoing redevelopment. A collaboration between the Bartlett Development Planning Unit at UCL, the Indian Institute for Human Settlements and the Latin American Social Science Facul...
Statement of Disbursements of the House
Covers receipts and expenditures of appropriations and other funds.
