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Geological Survey of Canada, Current Research (Online) no. 2002-C6
Formation resistivity factor and pore-surface resistivity values were determined for three mineralized & nonmineralized rock samples from the Giant mine & Con mine areas of the Yellowknife mining district. The purpose was to provide basic information required to understand the electrical conductivity mechanisms of these rocks and to aid interpretation of geophysical surveys conducted in these areas. This paper describes the methods & processes used to obtain the formation factor data & to document the results for use in future studies.
Voltage-Gated Ion Channels as Drug Targets
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
A Molecular Biology Approach to Parkinson's Disease
Parkinson's disease is the only neurodegenerative disorder for which the major pathological and biochemical defects have been identified. But why dopamine-containing cells in the substantia nigra die in Parkinson's disease remains a mystery. Similarly, the changes in basal ganglia output pathways which lead to the onset of motor disability and the occurrence of L-DOPA induced dyskinesia remain unclear. While treatment for the symptoms of Parkinson's disease is available, nothing can presently be done to stop the disease progressing. A molecular approach to Parkinson's disease is unraveling genetic factors responsible for inducing the onset of nigral cell degeneration or for making individual...
Mechanics of Poroelastic Media
In Mechanics of Poroelastic Media the classical theory of poroelasticity developed by Biot is developed and extended to the study of problems in geomechanics, biomechanics, environmental mechanics and materials science. The contributions are grouped into sections covering constitutive modelling, analytical aspects, numerical modelling, and applications to problems. The applications of the classical theory of poroelasticity to a wider class of problems will be of particular interest. The text is a standard reference for researchers interested in developing mathematical models of poroelasticity in geoenvironmental mechanics, and in the application of advanced theories of poroelastic biomaterials to the mechanics of biomaterials.
Trefftz and Fundamental Solution-Based Finite Element Methods
This reference explains hybrid-Trefftz finite element method (FEM). Readers are introduced to the basic concepts and general element formulations of the method. This is followed by topics on non-homogeneous parabolic problems, thermal analysis of composites, and heat conduction in nonlinear functionally graded materials. A brief summary of the fundamental solution based-FEM is also presented followed by a discussion on axisymmetric potential problems and the rotordynamic response of tapered composites. The book is rounded by chapters that cover the n-sided polygonal hybrid finite elements and analysis of piezoelectric materials. Key Features - Systematic presentation of 9 topics - Covers FEM...
Peptide and Protein Drug Delivery
This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Thermus Species
There is considerable interest in thermophile microorganisms, in their environments, their ability to survive at temperatures which normally denature proteins, but more importantly, as a valuable resource for bio technology. The first reported isolation of Thermus by Tom Brock was in 1969. This initiated the present era of thermophilic research with the realization that where liquid water is available, there may be no limits to the temper ature at which microorganisms can grow. Considerable research into the ecology, physiology, metabolism, and thermostable enzymes of thermo philes has led to their evaluation for a range of industrial and commercial processes. The past fifteen years have bee...
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry
Periostin
This book provides a comprehensive and up-to-date review of current understanding of periostin and its importance for human health and disease. Periostin is a secretory matricellular protein that has been revealed to play key roles in fibrillogenesis and cell migration, including metastasis of cancer cells. The production of periostin is upregulated during fibrotic responses and the mechanisms by which it promotes fibrosis have become a focus of interest owing to the potential clinical benefit to be derived from periostin blockade. In this book, readers will find coverage of all aspects, from the basic properties of periostin and its function as a scaffold for assembly of extracellular proteins through to its roles in bone and tissue regeneration, tumorigenesis, myocardial infarction, inflammatory and immune system disorders, and other diseases. Readers will also find the latest information on functions of periostin related to stemness and the application of periostin as a biomarker. It is hoped that the detailed knowledge of periostin and its pathobiological significance provided in this book will aid in the search for effective treatments for currently incurable diseases.
