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Biomolecular Forms And Functions: A Celebration Of 50 Years Of The Ramachandran Map
Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.
SRB's Manual of Surgery
The fourth edition of SRB’s Manual of Surgery brings trainee surgeons fully up to date with the latest procedures and techniques in general surgery. Each chapter examines both common and uncommon disorders that may occur in different parts of the body and the surgical procedures used to treat them. Malignancies are covered in greater detail in the new edition, discussing staging and current oncological trends. This 1336pp comprehensive manual includes 2200 full colour clinical photographs with detailed explanations, as well as boxes highlighting key physical signs to assist learning. The previous edition published in 2010. Key points 1350pp new edition bringing trainees up to date with latest procedures and techniques in general surgery Discusses common and less common conditions in all parts of the body Greater coverage of malignancies in the fourth edition 2200 full colour clinical photographs with explanations Includes key learning boxes highlighting physical signs Previous edition published in 2010
Biological Data Mining in Protein Interaction Networks
"The goal of this book is to disseminate research results and best practices from cross-disciplinary researchers and practitioners interested in, and working on bioinformatics, data mining, and proteomics"--Provided by publisher.
SRB's Clinical Methods in Surgery
This book is a comprehensive guide to clinical methods in surgery for medical students. Divided into six sections, the text begins with examination methods in general surgery. The following sections cover different body systems, trauma and orthopaedics. The third edition has been fully revised and updated and many new topics added. The book concludes with new chapters on X-rays, instruments and specimens for quick revision. Each chapter is presented in a step by step manner explaining history, clinical examination, investigations and differential diagnosis. Some topics include case studies and clinical pearls to assist learning. Key points are highlighted in colour boxes and the text is enhanced by more than 2100 images and illustrations, many of which are new to this edition. The book includes access to complimentary videos demonstrating examination techniques. Key points Fully revised, new edition explaining clinical methods in surgery Third edition features new chapters on X-rays, instruments and specimens Includes access to complimentary videos demonstrating examination techniques Previous edition (9789351525264) published 2015
Computational Knowledge Discovery for Bioinformatics Research
"This book discusses the most significant research and latest practices in computational knowledge discovery approaches to bioinformatics in a cross-disciplinary manner that is useful for researchers, practitioners, academicians, mathematicians, statisticians, and computer scientists involved in the many facets of bioinformatics"--
Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design
This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic ...
Function and Flexibility: Friend or Foe?
Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that “form follows function”. When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that “function follows form” as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original “1 gene - 1 protein structure - 1 function” relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interactin...
Prokaryotic Gene Regulation
This volume presents a collection of versatile methodologies to investigate prokaryotic gene regulation, with focus on the different levels of information processing and usefulness for various model organisms, whether archaeal, bacterial, or both. The chapters in this book are divided into four sections. Section One covers methods that enable the study of the structure of the bacterial/archaeal chromosome, the main template for all gene regulatory processes, and its epigenetic modification. Section Two looks at a selection of approaches that enable higher levels of understanding of transcription initiation, a key step in information processing. Section Three discusses the investigation of re...
Frontiers in Protein and Peptide Sciences
Frontiers in Protein and Peptide Sciences is a book series focused on leading-edge research on the structure, physical properties, and functions of proteins and peptides. Authors of contributions in this series have updated their work with new experimental data and references following their initial research. Each volume highlights a number of important topics in current research in the field of protein and peptide chemistry and molecular biology, including membrane proteins and their interactions with ligands, computational methods, and proteins in disease and biotechnology. The series is essential reading for protein chemists and researchers seeking the latest information about protein and peptide research.
