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Natural Antibodies in Health and Disease
Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behav...
The Origin of the Plasma Cell Heterogeneity
Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases.
Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Encyclopedia of Immunobiology
Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices
IMUNOLOGI DASAR
Buku ini membahas tentang imunologi dengan lebih rinci dan mendalam sesuai dengan pengetahuan yang dibutuhkan dalam imunologi dasar. Pembahasan dalam tiap bab dan sub bab dirancang secara jelas dan memperhatikan perkembangan dalam imunologi namun tidak terlalu panjang. Referensi yang digunakan adalah referensi-referensi yang mutakhir sehingga banyak hal baru yang bisa dilihat pada buku ini. Referensi lama kami gunakan jika tidak ditemukan referensi yang berumur kurang dari lima tahun dan hasil penelitian pada referensi tersebut masih relevan dengan imunologi masa kini. Di dalam buku ini juga memuat bab khusus yang membahas integrasi imunologi dengan ajaran islam. Kesemua hal tersebut menurut hemat kami merupakan sisi baik dari buku ini.
Molecular Biology of B Cells
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Nutrition and Fish Health
Safeguard the success of aquaculture operations without expensive antibiotics!Diseases are a major threat to the sustainability of the aquaculture industry. Because antibiotics have many drawbacks, increasing importance is being placed on understanding the mechanisms that make nutrition a key factor in host defense against pathogens. Nutr
Human B Cell Populations
B cells used to be considered as a homogeneous population of cells destined to produce antibodies of increasing affinity and to maintain an immunological memory. In recent years, it has been determined that B cells can be subdivided into different subsets characterized by distinct morphologic, phenotypic, and functional features. Presenting results of research work on the definition of B cell subset populations, this book explains the basic mechanisms that control B cell activation, stimulation and regulation. Articles include studies on both normal and malignant B cells and describe the mechanisms underlying T-B cell interactions during the immune response. The most important advances in the field of immunodeficiency are also reported. This volume will be essential not only for basic and clinical immunologists, but also for hematologists, pathologists and rheumatologists with a special interest in the pathogenesis of lymphoproliferative or autoimmune disorders.
