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Understanding Clinical Research
It is important for healthcare professionals to understand the basics of clinical research. This book offers a thorough explanation of the principles of clinical research, alongside a wide range of worked examples which show how these principles are applied in practice. Understanding Clinical Research takes readers from how to develop research questions, through the design of research studies, to disseminating research findings. Ethical considerations, research integrity, patient involvement, and study funding are all covered, along with an introduction to the key statistical methods needed for data analysis. Ideal for any healthcare professional: interested in understanding more about the development of evidence-based practice wanting to undertake research but not sure where to start considering or just starting a PhD / MD, or a PGCert in Research Studies
Rheumatology
A practical guide to the diagnosis and management of common rheumatic disorders, using real case histories. Alongside the development of national and international guidelines for the management of rheumatic disorders, there has been a huge growth in the availability of new therapies. This book summarises diagnosis and patient management based around the latest guidelines and expanded treatment options, including the scientific rationale upon which these treatments are based. To aid understanding, the book: features real case histories to illustrate the range of clinical presentations and how these can be managed covers all common rheumatic disorders, from rheumatoid arthritis through crystal arthropathies to fibromyalgia and chronic pain conditions includes a dedicated chapter on paediatric rheumatology provides advice on physiotherapy including links to recommended video demonstrations The book is written for clinicians, nurses and physiotherapists working in musculoskeletal medicine, in addition to GPs, and doctors preparing for the Specialist Certificate Examination in rheumatology.
Oxford Textbook of Rheumatoid Arthritis
The Oxford Textbook of Rheumatoid Arthritis" covers all relevant aspects of the fisease, ranging from basic science, epidemiology, clinical and laboratory assessments, drug and non-drug treatments, and disease outcomes. Written by an international team of experts, it will be an invaluable resource for those involved with people with RA.
General Medicine and Surgery
“I like the unique style ... It is simple, engaging and easy to read, whatever your learning preferences (I particularly like the colour coding!). It also covers topics comprehensively, making it not only a great aide-memoire but also a very useful everyday book on the ward.” From the Foreword by Professor Farah Bhatti OBE, Consultant Cardiothoracic Surgeon All the core knowledge you need at medical school in one place! General Medicine and Surgery: Medical Student Revision Guide contains the core information you need on: Cardiology; Endocrinology; Gastroenterology; Hepato-pancreato-biliary; Haematology; Immunology & Allergy; Neurology; Renal; Respiratory; General surgical principles; Th...
Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Recent advances in the understanding of microbiota in health and diseases are presented in this special issue of Frontiers in Immunology and Frontiers in Microbiology as well as their impact on the immune system that can lead to the development of pathologies. Potential perspectives and biomarkers are also addressed. We offer this Research Topic involving 64 articles and 501 authors to discuss recent advances regarding: 1. An overview of the human microbiota and its capacity to interact with the human immune system and metabolic processes, 2. New developments in understanding the immune system’s strategies to respond to infections and escape strategies used by pathogens to counteract such responses, 3. The link between the microbiota and pathology in terms of autoimmunity, allergy, cancers and other diseases.
Regulatory potential of post-translational modifications in bacteria
Post-translational modifications (PTMs) are widely employed by all living organisms to control the enzymatic activity, localization or stability of proteins on a much shorter time scale than the transcriptional control. In eukarya, global analyses consistently reveal that proteins are very extensively phosphorylated, acetylated and ubiquitylated. Glycosylation and methylation are also very common, and myriad other PTMs, most with a proven regulatory potential, are being discovered continuously. The emergent picture is that PTM sites on a single protein are not independent; modification of one residue often affects (positively or negatively) modification of other sites on the same protein. Th...
Clinical Integration: Surgery
Surgical cases explained! Clinical Integration: Surgery helps medical students and junior doctors link basic medical science with clinical context and build an appreciation of how pathophysiology manifests as recognisable clues. The book shows readers the logical connections between patient history, examination findings, investigation results, management rationale and their underlying mechanisms. Readers learn to understand the “why and how” behind the diagnosis, investigation and management of common clinical problems. The book takes a system-based approach to cover common surgical cases, from aortic stenosis to varicose veins, via diverticulitis and pressure ulcers. Every case uses a consistent format to: highlight the key elements of the history, examination and investigations offer a guide to management options provide rapid access to important facts
Osteoarthritis Biomarkers and Treatments
This book presents exclusive and comprehensive insight into the detailed molecular mechanisms of osteoarthritis (OA) initiation, progression and current advancements in the field. Inputs from clinician scientists, research and expertise offer a complete explanation of the current understanding of the pathogenesis of OA and practice in imaging and treatments strategies. Contributions from leading scientists provide a detailed introduction in the use of biomarkers in clinical research as well as in clinical practice and OA diagnosis. This book further discusses the potential of regenerative therapies and recent advances in cardiovascular and functional capacity on patients with OA.
Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders
The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.
