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Current Challenges in Modeling Cellular Metabolism
Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the s...
Synthetic Biology-Guided Metabolic Engineering
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Affectionate Authorities
In one of his sermons, the medieval preacher Bernardino of Siena listed seven ’fathers’ to whom one owed obedience: God, one’s natural father, godfather, confessor, benefactor, a government official, and any elderly man. This book seeks to answer the question of why medieval Europeans saw the need for so many ’fathers.’ Why was fatherhood so appealing as a metaphor? Situated at the intersection of social and cultural history, the study draws upon a variety of late-medieval and early-modern sources including witness depositions, personal letters and pedagogical treatises from the city of Basel, Switzerland. It focuses on how people from different walks of life invoked ideas about fa...
Methoden der Bioinformatik
Schritt für Schritt zu den Konzepten Die Autoren führen den Leser von den mathematischen Grundlagen zu den konkreten Methoden der Bioinformatik. Das Buch wendet sich damit an alle, die bioinformatische Methoden und Softwarepakete verwenden wollen, sie aber nicht als Black Boxes akzeptieren möchten. Ein besonderes Highlight ist die schrittweise Implementierung wichtiger Algorithmen der Bioinformatik im Computeralgebra-Programm Mathematica, um die Konzepte auch auf der informatischen Ebene zu verstehen. Das Themenspektrum reicht von bioinformatischen Alltagsfragen bis in die Systembiologie. Die zweite, stark erweiterte Auflage geht auch auf eine Reihe sehr aktueller Themen der Bioinformatik ein, etwa Next-Generation Sequencing (NGS), GWAS-Daten und Protein-Interaktions-Netzwerke. Der Inhalt ist spannend und leicht verständlich.
Fundamental Bioengineering
A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging "white" biotechnology industry. As such, this latest volume in the "Advanced Biotechnology" series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given. With contributions from leading experts in industry and academia, this is a comprehensive source of information peer-reviewed by experts in the field.
