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Polypharmacology
Practical guide to navigate problems involved with promiscuous ligands and multi-target drug discovery, supported by case studies and real examples Polypharmacology covers the two-sided nature of polypharmacology: its relevance for adverse drug effects, as well as its benefit for certain therapeutic drug classes in effectively treating complex diseases like psychosis and cancer. The book provides practical guidelines and advice to help readers design drugs that have multiple targets while minimizing unwanted off-target effects, discusses important disease areas like viral infection, diabetes, and obesity that have advanced significantly in the last decade, and guides researchers in neighbori...
Lead Generation, 2 Volume Set
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time. Beginning with a general discussion of the underlying principles and strategies, individual lead generation approaches are described in detail, highlighting their strengths and weaknesses, along with all relevant bordering disciplines like e.g. target identification and validation, predict...
GoPro
WHERE INSPIRATION MEETS TECHNICAL CRAFT, this guide to professional filmmaking with a GoPro is packed with hundreds of beautiful photos and interactive links to videos created by professional athletes, filmmakers, and inspired GoPro users around the world. As the only book to cover the art and technique of advanced filmmaking by the team at GoPro, you’ll get a unique insider’s look at GoPro’s history, all the different camera modes and settings, standard and experimental mounts, shooting principles, and editing techniques. Compelling stories from users such as Kelly Slater, Shaun White, and Kevin Richardson offer a rare view into an incredible world of athleticism, artistic beauty, and storytelling. Whether you’re a professional filmmaker, top athlete or an aspiring enthusiast, you’ll get all the inspiration and instruction you need to capture and create your own engaging edits to share with the world. “This book is an invaluable window into Bradford and Brandon’s creative thinking and summarizes their years of experience. Hopefully it serves as a spark for you just as the authors have done for GoPro.” From the foreword by Nicholas Woodman, founder of GoPro
Comprehensive Medicinal Chemistry III
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Major Companies of Europe, 1999
This annual directory has been revised and updated for 1999 to provide a comprehensive source of information on the major public and private companies of Western Europe. It includes detailed information on each of the 24,000 companies featured over the four volume set.
Lead Generation
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time. Beginning with a general discussion of the underlying principles and strategies, individual lead generation approaches are described in detail, highlighting their strengths and weaknesses, along with all relevant bordering disciplines like e.g. target identification and validation, predict...
Drug Selectivity
The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Anticancer Research
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The Trade Commissioner
When a Scandinavian Trade Commissioner to North America finds out that one of his guests to a wine tasting party had been one of Hitler's Aides-de-Camp, it leads to International Industrial Espionage involving murder, extortion and the chance to make a fortune from newly discovered Siberian diamond deposits. As Trade Commissioner for a Scandinavian country with responsibility for trade development with Northwestern USA and Western Canada, Eric Stark learns through his secretary that a German on his invitation list for a wine tasting party at the end of the 1960's had been one of Hitler's aides-de-camp during the entire second world war. When learning from his old friend at La Surete in Paris...
