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Progress Report
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Apoptosome
"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome. The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis. This book will be a valuable resource for researchers investigating the rol...
Evolution in the Dark
How organisms come to possess adaptive traits is a fundamental question for evolutionary biology. Although it is almost impossible to demonstrate evolution in the laboratory, this issue can be approached by using an unusual organism, “Dark-fly”: Drosophila melanogaster kept in complete darkness for 57 years through 1,400 generations, which corresponds to 28,000 years in terms of human generations. Has Dark-fly adapted to an environment of total darkness? If so, what is the molecular nature of the adaptation? In Evolution in the Dark, the remarkable findings from the Dark-fly project performed at Kyoto University are presented. It was found that Dark-fly did not have poor eyesight, but ra...
Progress in Clinical Parasitology
This volume, now the third in a series, presents a more hetero geneous content than previous issues. It covers two previously rare but now common opportunistic infections in the United States, a common parasitic disease in Japan, exciting but difficult problems in developing a malarial vaccine, a study exemplifying the role of T lymphocytes in parasitic infections, and a fascinating review of the relationship between the schistosomes and their molluscan hosts. The first chapter covers cryptosporidiosis, which has become a household name since the outbreak of the acquired immunodeficien cy syndrome (AIDS). However, infection is now recognized to occur widely in immunocompetent individuals, wi...
Wakatta! Course Book
Wakatta! has been written for senior high school students continuing their study of Japanese. The course is constructed around key topic area s. It is designed to develop essential skills for effective oral and wri tten communication in Japanese. Wakatta! covers two years' study and can be used as the core component of any senior high school course. The Wakatta! Course integrates three resources: a Course Bo ok of twelve well-balanced units of work, each of which includes essenti al vocabulary, kanji characters, reading texts, explanations of language patterns and consolidation of the topic area two workbooks wit h wide range of activities and exercises in reading, writing, speaking, listening, grammar and kanji as well as puzzles, role-plays and dialogue s 7 audio tapes featuring oral texts and listening exercises Wakatta! is user-friendly, student focused and has several o utstanding features: comprehensive, straightforward explana tions of Japanese language structure with numerous examples gra ding of listening exercises into three levels to cater foe all abilities an extensive variety of activities to make learning practical and exciting Kanji organised into each topic unit
Heat Shock Proteins in Cancer
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
