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Biographical Memoirs
This distinguished series contains the biographies of deceased members of the National Academy of Sciences and bibliographies of their published works. Each biographical essay was written by a member of the Academy familiar with the professional career of the deceased. A cumulative index for all 57 volumes is now included. For historical and bibliographical purposes, these volumes are worth returning to time and again. Volume 57 includes biographies of: Arthur Francis Buddington, J. George Harrar, Paul Herget, John Dove Isaacs III, Bessel Kok, Otto Krayer, Rebecca Craighill Lancefield, Harold Dwight Lasswell, Jay Laurence Lush, John Howard Mueller, Robert Franklin Pitts, John Robert Raper, Karl Sax, Gerhard Schmidt, Leslie Spier, Hans-Lukas Teuber, and Warren Weaver.
The Nervous System
Physiological Pharmacology: A Comprehensive Treatise, Volume IV: The Nervous System — Part D: Autonomic Nervous System Drugs focuses on the effects of drugs on the nervous system, including how adrenergic drugs affect the heart and systemic circulation, metabolism, and adrenergic compounds. The selection first offers information on the effects of adrenergic drugs on the heart and systemic circulation. Topics include actions of adrenergic drugs, possible drug actions on the heart, epinephrine and arterenol, and other sympathomimetic drugs. The book then examines the effects of adrenergic compounds on pulmonary circulation, including physiologic considerations and general considerations of adrenergic compounds. The manuscript ponders on the effects of adrenergic agents on smooth muscles other than those of the vascular system and the effects of sympathomimetic amines and adrenergic blocking agents on metabolism. The book also touches on veratrum alkaloids and neurotoxins, as well as botulism, tetanus, therapeutic use, and chemistry of veratrum alkaloids. The selection is a dependable reference for readers interested in the effects of drugs on the nervous system.
Cholinesterases and Anticholinesterase Agents
Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agen...
Antineoplastic and Immunosuppressive Agents
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a. single volume the entire field of drugs em ployed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reason...
Hypolipidemic Agents
The major cause of death in the Western world is some form of vascular disease; and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known about the etiology and treatment of ASHD, there is, as yet, no specific means of prognosis of an impending coronary episode. There are, however, several indications of susceptibility to coronary disease, generally known as risk factors, the foremost of which is hyperlipidemia. Hyperlipidemia is more commonly designated as hypercholesteremia or triglyceridemia, depending upon which moiety is elevated, but since lipids are transported in the blood as members of a lipoprotein complex, the most descriptive general term wou...
Histamine and Anti-Histaminics
It was an agreable, though strenuous task to edit a book with so many distin guished contributors, on a subject to which I have given half of my life. In 1959, when Prof. O. EICHLER invited me to edit a book on "Histamine and Anti histaminics", as a supplement to HEFFTER'S Handbuch, I thought the task could be done in three years. Now, five years are gone and only half is fulfilled. Though, so far as the "Histamine" part of the book is concerned, the initial plan has been followed very closely, we had to leave the Anti-histaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on M utterkorn, by ARTHUR R. CUSHING were considered enough, in vol. II,...
Drug Addiction II
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Neurohypophysial Hormones and Similar Polypeptides.
production of this volume of the Handbook. If this joint enterprise has succeeded it is thanks to their competence, knowledge and application, for the editor's role is merely that of a coordinator. My thanks are also due to Springer-Verlag, the publishers, who gave me every possible assistance in seeing this volume to completion. Dr. D. Maroske was kind enough to prepare the Subject Index. And lastly I should like to voice my indebtedness to the Management of Sandoz Ltd., Basle, which allowed me to devote a not inconsiderable part of my time to the editing of this volume. I am also very grateful to a number of members of the staff of Sandoz Ltd.: to Mr. J.E. Smith, B. Sc., F.1. L., who translated some chapters and revised the language of others and to Miss Hannelore Straube and Miss Sonja Ebner for their valuable secreterial help.
