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Endothelial Dysfunction During Inflammation and Alloimmunity
Endothelial cells form the inner lining of blood and lymphatic vessels and they have frequent interactions with immune cells as well as foreign agents. Endothelial function is crucially involved in physiologic immunity at different stages including recruitment of leukocytes, angiogenesis and tissue repair. Endothelial dysfunction is a not well-defined term, it is widely used to describe the non-physiologic activity of endothelial cells. It has been suggested that endothelial dysfunction plays a role in a variety of human diseases, such as arteriosclerosis, cancer, autoimmunity and sepsis. More recently, a role of lymphatic endothelial cells as well as vascular endothelial cells in the pathop...
Methods in Alloimmunity and Transplantation: 2023
This series aims to highlight the latest experimental techniques and methods used to investigate fundamental questions in Immunology research, with a focus on Alloimmunity and Transplantation. Review articles or opinions on methodologies or applications including the advantages and limitations of each are welcome. This Topic includes technologies and up-to-date methods which help advance science. The contributions to this collection will undergo peer review. Novelty may vary, but the utility of a method or protocol must be evident. We welcome contributions covering all aspects of Alloimmunity and Transplantation. Submissions will be handled by the team of Topic Editors in the respective sections.
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantati...
The EBMT Handbook
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Effects of cell interactions at the endothelium in leukocyte differentiation and polarization during inflammation
A complex exchange of signals between endothelial cells and tissues occurs during steady-state and in inflammatory conditions. These interactions involve numerous cell types including an active contribution from endothelial cells and occur on both sides of the endothelial monolayer. In addition to functioning as selective permeability barriers, it is increasingly recognized that local cell attraction to endothelial cells provides the potential for focal interactions between relevant cells. In this context, cellular interactions taking place at the surface of the endothelium and within the perivascular spaces are thought to initiate crucial steps in the generation and shaping of immune respon...
Tailoring NK Cell Receptor-Ligand Interactions: an Art in Evolution, 2nd Edition
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the un...
Asymmetrische Kriege
Asymmetrische Kriege bilden die größte sicherheitspolitische Herausforderung unserer Zeit. Doch was ist ein asymmetrischer Krieg und wodurch unterscheidet er sich von konventionellen Staatenkriegen? Wie kann er geführt, wie verhindert werden? Felix Wassermann sichtet die jüngere politikwissenschaftliche Asymmetrie-Diskussion und bringt Klarheit in die unübersichtliche Sicherheitslage nach dem Ende des Kalten Krieges. Unter ideengeschichtlichem Rückgriff auf Metaphern und Theorien der Asymmetrie rekonstruiert der Autor den Asymmetrie-Diskurs vom Scheitern der USA im Vietnamkrieg über die Terroranschläge vom 11. September 2001 bis zu den globalen, transnationalen Risiken des 21. Jahrhunderts.
