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Immuno-Oncology
Over the last decade, immuno-oncology has witnessed an astonishing pace of discovery and innovation translating into unprecedented successes in the clinical setting, arguably representing one of the most profound and transforming revolution in the history of cancer therapy. This book provides a concise and accurate outline of the main developments in major tumor types including melanoma, lung, breast, brain and renal cell cancers. In addition, transversal chapters that describe the commonalities of some of the therapeutic strategies are provided to cover topics like immune checkpoint biology, T cell engineering or rational combination therapies. Each chapter has been authored by senior key o...
Computational Structural Biology
This work covers the impact of computational structural biology on protein structure prediction methods, macromolecular function and protein design, and key methods in drug discovery. It also addresses the computational challenges of experimental approaches in structural biology.
Bioinformatics: A Swiss Perspective
Biological research and recent technological advances have resulted in an enormous increase in research data that require large storage capacities, powerful computing resources, and accurate data analysis algorithms. Bioinformatics is the field that provides these resources to life science researchers.The Swiss Institute of Bioinformatics (SIB), which has celebrated its 10th anniversary in 2008, is an institution of national importance, recognized worldwide for its state-of-the-art work. Organized as a federation of bioinformatics research groups from Swiss universities and research institutes, the SIB provides services to the life science community that are highly appreciated worldwide, and...
Successes and Limitations of Targeted Cancer Therapy
The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.
Tumor Immunology and Cancer Vaccines
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Cancer II
This book reviews recent breakthroughs in anti-cancer drug discovery. Building on the previous volume in the series, it outlines some of the most significant developments that have occurred in the field in the subsequent period that have led to new drug approvals or promising clinical candidates. The volume is divided into chapters that each relate to a specific protein or protein class. Each chapter provides an overview of the underlying biology and then emphasises the medicinal chemistry strategies and tactics that led to the most significant drugs and drug candidates. A summary of clinical data and the future outlook for the field is also provided. Each chapter is authored by experts in the topic and who have themselves made significant contributions to their respective fields.
Computational Approaches in Biotechnology and Bioinformatics
Volume 1 of Computational Approaches in Bioengineering—Computational Approaches in Biotechnology and Bioinformatics—explores many significant topics of biomedical engineering and bioinformatics in an easily understandable format. It explores recent developments and applications in bioinformatics, biomechanics, artificial intelligence (AI), signal processing, wearable sensors, biomaterials, cell biology, synthetic biology, biostatistics, prosthetics, big data, and algorithms. From applications of biomaterials in advanced drug delivery systems to the role of big data, AI, and machine learning in disease diagnosis and treatment, the book will help readers understand how these technologies a...
Protecting Privacy through Homomorphic Encryption
This book summarizes recent inventions, provides guidelines and recommendations, and demonstrates many practical applications of homomorphic encryption. This collection of papers represents the combined wisdom of the community of leading experts on Homomorphic Encryption. In the past 3 years, a global community consisting of researchers in academia, industry, and government, has been working closely to standardize homomorphic encryption. This is the first publication of whitepapers created by these experts that comprehensively describes the scientific inventions, presents a concrete security analysis, and broadly discusses applicable use scenarios and markets. This book also features a colle...
Graphs in Biomedical Image Analysis, and Overlapped Cell on Tissue Dataset for Histopathology
This LNCS conference volume constitutes the proceedings of the MICCAI Workshop GRAIL 2023 and MICCAI Challenge OCELOT 2023, Held in Conjunction with MICCAI 2023, Vancouver, BC, Canada, September 23, and October 4, 2023. The 9 full papers (GRAIL 2023) and 6 full papers (OCELOT 2023) included in this volume were carefully reviewed and selected from GRAIL 14 (GRAIL 2023) and 6 (OCELOT 2023) submissions. The conference GRAIL 2023 a wide set of methods and application and OCELOT 2023 focuses on the cover a wide range of methods utilizing tissue information for better cell detection, in the sense of training strategy, model architecture, and especially how to model cell-tissue relationships.
Process Mining Workshops
This book constitutes revised selected papers from the International Workshops held at the Second International Conference on Process Mining, ICPM 2020, which took place during October 4-9, 2020. The conference was planned to take place in Padua, Italy, but had to be held online due to the COVID-19 pandemic. The conference focuses on the area of process mining research and practice, including theory, algorithmic challenges, and applications. The co-located workshops provided a forum for novel research ideas. The 29 papers included in this volume were carefully reviewed and selected from 59 submissions. They stem from the following workshops: 1st International Workshop on Event Data and Behavioral Analytics (EDBA) 1st International Workshop on Leveraging Machine Learning in Process Mining (ML4PM) 1st International Workshop on Streaming Analytics for Process Mining (SA4PM'20) 5th International Workshop on Process Querying, Manipulation, and Intelligence (PQMI) 3rd International Workshop on Process-Oriented Data Science for Healthcare (PODS4H) 1st International Workshop on Trust and Privacy in Process Analytics (TPPA)
