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It is an insidious illness with no known cure, afflicting those who suffer from it with near-uncontrollable tremors, speech impairment, and balance problems. In addition, one's intelligence experiences decline. Among its most prominent victims are Muhammad Ali and Michael J Fox. Parkinson's disease is a disorder of certain nerve cells in the brain that produce dopamine, which is a chemical messenger that the brain uses to help direct and control movement. In Parkinson's disease, these dopamine-producing nerve cells break down, dopamine levels drop, and brain signals directing movement become abnormal. Usually, the disease begins in later life (in one's 50s or after), although there are cases...
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Parkinson’s Disease and Nonmotor Dysfunction fills a major gap in the current rapidly growing body of knowledge concerning Parkinson’s disease. Drs. Pfeiffer and Bodis-Wollner have correctly perceived that many nonmotor features of Parkinson’s disease are given insufficient attention in the medical literature. Unfortunately, they are often also given insufficient attention by the practicing neurologists who see these patients. As recently pointed out, there is clearly much more to Parkinson’s disease than depletion of the nigrostriatal dopamine system (1). Parkinson’s disease (not just m- tiple system atrophy) is a multisystem disorder, both pathologically and in its clinical manif...
Includes subject section, name section, and 1968-1970, technical reports.
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First multi-year cumulation covers six years: 1965-70.
This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.