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This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.
Vorwort Die vorliegende Arbeit entstand während meiner Tätigkeit als wissenschaftlicher Mitarbeiter am Lehrstuhl für Marketing an der Universität Bayreuth. Ihr Zustandekommen wurde von vielen Menschen unterstützt. Diesen Menschen möchte ich an dieser Stelle für ihre vielfältige Unterstützung danken. An erster Stelle gilt mein Dank meinem Doktorvater, Herrn Prof. Dr. Heymo Böhler, für die wertvollen Anregungen, die inhaltlichen Freiräume und die sehr lehrreiche Zeit an seinem Lehrstuhl. Mein weiterer Dank gilt Prof. Dr. Andreas Remer und Prof. Dr. Herbert Woratschek, die bereitwillig das Koreferat bzw. den Prüfungsvorsitz übernahmen. Für Ihre Anregungen und die stets heiter-kon...
Dirk Haid zeigt die Wesensmerkmale des Corporate Entrepreneurship auf und untersucht, wann und aus welchen Gründen unternehmerisches Handeln für etablierte Firmen Erfolgspotentiale schafft. Er stellt Gestaltungsinstrumente für eine Implementierung des Corporate Entrepreneurship vor und verdeutlicht, unter welchen Voraussetzungen sie dazu beitragen, den Erneuerungsfaktor in das Unternehmen zu integrieren.
Dino Scigliano entwickelt einen konzeptionellen Bezugsrahmen für das Management radikaler Innovationen und zeigt dessen Gestaltungsoptionen auf.
An alphabetical list of all business firms and private citizens; a classified business directory, and a directory of the public institutions; together with a map from the latest surveys: and complete street guide.
The provision of optimal dialysis therapy to children requires a thorough understanding of the multi-disciplinary manner in which the pediatric patient is affected by renal insufficiency. Knowledge of the technical aspects of peritoneal dialysis, hemodialysis and continuous renal replacement therapy must be complemented by attention to issues such as anemia, renal osteodystrophy, hypertension, growth, cognitive development, nutrition, nursing care and the psychosocial adaptation of the child and family to chronic disease. The inaugural edition of Pediatric Dialysis provides a comprehensive review of these and other related topics with a singular emphasis on the unique aspects of their application to children. With authoritative, clinically relevant, well-referenced chapters written by a host of recognized international experts who emphasize key aspects of contemporary management, Pediatric Dialysis has been designed to serve as a primary resource to all clinicians involved in the care of the pediatric dialysis patient.
Includes reports of the heads of the various municipal departments.
A significant medical event is expected in 1992: the first human use of a fully implantable, long-term cardiac assist device. This timely volume reviews the artificial heart program-and in particular, the National Institutes of Health's major investment-raising important questions. The volume includes: Consideration of the artificial heart versus heart transplantation and other approaches to treating end-stage heart disease, keeping in mind the different outcomes and costs of these treatments. A look at human issues, including the number of people who may require the artificial heart, patient quality of life, and other ethical and societal questions. Examination of how this technology's use can be targeted most appropriately. Attention to achieving access to this technology for all those who can benefit from it. The committee also offers three mechanisms to aid in allocating research and development funds.