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Professor, Dr.Sc. Valentin A. Stonik is one of the pioneers in marine natural products chemistry. His specialisms are in the structure and properties of biological active natural compounds from marine invertebrates, especially echinoderms and sponges. His interests include the regulation of secondary metabolism, structural studies of alkaloids, unusual lipids, isoprenoids, polyhydroxysteroids, glycosides of polyhydroxysteroids, steroid, triterpenoid oligoglycosides, carbohydrates and other natural products, as well as the investigation of the biological activities, biosynthesis, chemotaxonomy and chemical evolution of secondary metabolites. He is the author and co-author of around 500 scient...
The G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences (PIBOC FEB RAS) was founded in 1964 in Vladivostok in the Far East of Russia. Over many years, we have been carrying out studies on the natural products of both marine and terrestrial origin. In collaboration with many Russian and foreign scientists, we have investigated many hundreds of diverse biomolecules, including steroids and terpenoids, quinoid compounds and alkaloids, polysaccharides and lipids, enzymes and lectins, proteins, and peptides. The Institute has a collection of marine microorganisms (KMM) PIBOC, which includes more than 4000 strains of marine bacteria and more than 1000 strains of marine fungi. The biological activity of natural compounds is also being studied. This book includes the 14 manuscripts which covered almost all aspects of PIBOC research activity in the fields of bioorganic chemistry, biochemistry, organic synthesis of natural compounds, marine microbiology, and genetic engineering, and we hope it will provide interesting new information for scientists working in these fields.
The books described marine glycoconjugates. Two articles concern microalgal metabolites such as steroid and sphingoid glycoconjugates, and a glycoprotein from a sea cucumber with interesting biological activities, respectively. One article discusses the fatty acid composition and thermotropic behavior of glycolipids and other membrane lipids of green macrophyte Ulva lactuca. Three articles cover lectin subjects. One review article analyzes perspectives of marine and freshwater lectins’ application in experimental oncology and the therapy of oncological diseases; another article describes the use of a sponge lectin in the construction of a recombinant virus. The third article concerns the f...
In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.
This book contains information for specialists in various fields of science. From the point of view of pharmacology, data are reported regarding the effect of echinochrome A and related metabolites from sea urchins on the survival and functional properties of stem cells, which can facilitate ex vivo application of this compound in medicine. For scientists who isolate and establish structures of marine natural compounds, an article devoted to the proof of the microbial origin of a typical metabolite earlier found exclusively from marine invertebrates, 6-epi-monanchorin, may also be of interest. A range of new marine metabolites was discovered from the both marine invertebrates and marine micr...
This publication is based upon work from COST Action ’16203 MARISTEM Stem cells of marine/aquatic invertebrates: from basic research to innovative applications’, supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. www.cost.eu Aquatic invertebrates represent the largest biodiversity and the widest phylogenetic radiation on Earth, with more than 2 million known species. Up until a...
This volume presents frontier reviews of recent developments in bioactive natural products in cutting-edge areas by eminent experts in their respective fields. It is an essential addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic. • The first seven reviews cover recent developments in the field of bioactive marine natural products.• Additional coverage includes Novel Domino reactions; medicinal plants and phytochemicals; recent developments in bioactive natural peptides; the chemistry and pharmacology of natural cyclic lipopeptides; and the biological activities of Salvia .• The text includes a comprehensive review of biologically active compounds of semi-metals such as boron, silicon, arsenic, selenium and tellurium.
This book is a printed edition of the Special Issue "Marine Compounds and Cancer" that was published in Marine Drugs