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Prions
Prions are disease-causing agents that are neither bacterial nor fungal nor viral and contain no genetic material. A prion is a protein that occurs normally in a harmless form. By folding into an aberrant shape, the normal prion turns into a rogue agent. It then co-opts other normal prions to become rogue prions. Prions have been held responsible for a number of degenerative brain diseases, including scrapie (a fatal disease of sheep and goats), mad cow disease, Creutzfeldt-Jacob disease, fatal familial insomnia, kuru, an unusual form of hereditary dementia known as Gertsmann-Straeussler-Scheinker disease, and possibly some cases of Alzheimer's disease. This book presents the latest research in this dynamic field.
Neurodegenerative Diseases
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Neuroimaging for Clinicians
Neuroimaging for clinicians sourced 19 chapters from some of the world's top brain-imaging researchers and clinicians to provide a timely review of the state of the art in neuroimaging, covering radiology, neurology, psychiatry, psychology, and geriatrics. Contributors from China, Brazil, France, Germany, Italy, Japan, Macedonia, Poland, Spain, South Africa, and the United States of America have collaborated enthusiastically and efficiently to create this reader-friendly but comprehensive work covering the diagnosis, pathophysiology, and effective treatment of several common health conditions, with many explanatory figures, tables and boxes to enhance legibility and make the book clinically useful. Countless hours have gone into writing these chapters, and our profound appreciation is in order for their consistent advice on the use of neuroimaging in diagnostic work-ups for conditions such as acute stroke, cell biology, ciliopathies, cognitive integration, dementia and other amnestic disorders, Post-Traumatic Stress Disorder, and many more
Neurobiology of Brain Disorders
Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegene...
What is Kuru? A Deadly First Human Prion (misfolded proteins)Disease.
What is Kuru? A Deadly First Human Prion (misfolded proteins)Disease. Kuru is an incurable and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea. Kuru, the first human prion disease was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). The discovery of kuru opened new vistas of human medicine and was pivotal in the subsequent transmission of Creutzfeldt–Jakob disease, as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century. An attempt is made here to summarize the history of this seminal discovery, epidemiology, clinical picture, neuropathology, investigations, management, complications, prognosis and the descriptions of electron microscopy and confocal microscopy of kuru amyloid plaques along with several illustrations for better understanding of a quaint but interesting entity. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London).
The Ultrastructure of Human Tumours
The Ultrastructure of Human Tumours: Applications in Diagnosis and Research describes the core features as seen by transmission electron microscopy, defining the different types of cellular differentiation in tumours; this is relevant for tumour nomenclature and diagnosis, which, in turn, are important for tumour pathologists in their collaboration with oncologists for the treatment of cancer patients. The book is divided into 8 chapters. Following an introduction on technique and procedure, there are chapters on epithelial tumours, melanocytic lesions, soft-tissue and related tumours, lymphoma and leukaemia, CNS neoplasms and neuroendocrine and neuronal tumours. Each chapter includes an int...
Encyclopedia of Movement Disorders
The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made ...
Diagnostyka laboratoryjna
Diagnostyka laboratoryjna. Poradnik kliniczny to kompendium skierowane do lekarzy praktyków, w tym lekarzy medycyny rodzinnej, a także diagnostów laboratoryjnych wszystkich specjalności. Książka ta jest również doskonałym uzupełnieniem wiadomości z zakresu diagnostyki laboratoryjnej dla studentów analityki medycznej. Zawarto w niej nie tylko informacje o badaniach i testach laboratoryjnych, ale, co bardzo ważne, omówiono również elementy fazy przedanalitycznej, dotyczące tego, jak przygotować pacjenta do badania laboratoryjnego, jak pobrać krew i do jakiego rodzaju próbówek, w jakiej temperaturze i czasie należy próbkę transportować, aby materiał do badań dostarczyć do laboratorium. W podręczniku przedstawiono też fazę postanalityczną, w której dla różnych testów laboratoryjnych opisano przyczyny uzyskiwania wyników fałszywie dodatnich i ujemnych, a także wpływ czynników interferujących na fazę analityczną poszczególnych badan laboratoryjnych.
