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This volume focuses on latest research in therapeutic devices for cardiovascular, i.e. vascular and valvular and cardiac diseases. In the area of vascular therapies, aspects covered relate to latest research in small-diameter tissue-regenerative vascular grafts, one of the greatest persisting challenges in cardiovascular therapies, stent grafts and endovascular stents for percutaneous arterial interventions. Contributions on valvular therapies focus on tissue engineered and tissue regenerative prosthetic heart valves and valvular prostheses for trans-apical implantation including the challenges posed on the prosthesis design. The section on cardiac diseases aims at covering therapeutic advances for myocardial infarction and prevention of heart failure and on in vivo biomechanics of implantable cardiac pacemaker devices. A further section complements these three areas by presenting constitutive modelling of soft biological tissues of the cardiovascular system, an area imperative for advanced numerical and computational modelling in the development and optimisation of cardiovascular devices and therapies.
The safety, effectiveness, and utility of medical nanorobotic devices will critically depend upon their biocompatibility with human organs, tissues, cells, and biochemical systems. In this Volume, we broaden the definition of nanomedical biocompatibility to include all of the mechanical, physiological, immunological, cytological, and biochemical re
This groundbreaking single-authored textbook equips students with everything they need to know to truly understand the hugely topical field of biomaterials science, including essential background on the clinical necessity of biomaterials, relevant concepts in biology and materials science, comprehensive and up-to-date coverage of all existing clinical and experimental biomaterials, and the fundamental principles of biocompatibility. It features extensive case studies interweaved with theory, from a wide range of clinical disciplines, equipping students with a practical understanding of the phenomena and mechanisms of biomaterials performance; a whole chapter dedicated to the biomaterials industry itself, including guidance on regulations, standards and guidelines, litigation, and ethical issues to prepare students for industry; informative glossaries of key terms, engaging end-of-chapter exercises, and up-to-date lists of recommended reading. Drawing on the author's 40 years' experience in biomaterials, this is an indispensible resource for students studying these lifesaving technological advances.
This Research Topic celebrates the 50th anniversary of the first heart transplant performed in December of 1967 in Cape Town, South Africa. Cardiovascular researchers met in South Africa in December 2017 to commemorate this event, presenting an opportune time to reflect on the achievements of applied cardiovascular research and highlight forthcoming technology developments that will shape the future of cardiovascular medicine. The clinical breakthrough in 1967 offered hope to many patients suffering with cardiac complications, and these life-saving surgeries continue to have a tremendous impact. Tissue shortages, surgical risks, and complications due to improper host-transplant tissue intera...
This unique book by leading experts reviews the key therapeutic issues related to stem cell technology.
First multi-year cumulation covers six years: 1965-70.
Alex Walker just wants to find peace. Growing up in a dysfunctional blue-collar family, he learns to navigate life, carrying heavy emotional baggage from years of abuse and neglect. Trouble follows Alex through the hills of suburban Philadelphia to a rural trade school, where he travels down a dark path. While on probation, Alex joins a ragtag 90s cover band which teaches him that life doesn’t have to be so dramatic.
While many high-income countries observe a relative decline in the population impact of heart disease and deal with the problem of an older patient population who readily survive earlier non-fatal encounters with the condition, Africa contends with a typically younger population with frequently advanced and often fatal heart disease. While high-income countries exclusively deal with non-communicable forms of heart disease, Africa contends with both communicable and non-communicable forms of heart disease. Designed to provide anyone with an interest in heart disease in Africa with an immediate sense of how the area is progressing from a clinical to research perspective in responding to this evolving epidemic Presents salient research uncovering the evolving burden of communicable and non-communicable forms of heart disease, Includes content on maternal heart disease, infant and childhood heart disease, risk and prevention, heart failure and other common forms of heart disease in rural and urban communities in Africa.
Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the treatment of this important and wide-ranging group of diseases that affect a large proportion of the world po- lation. This book is based on lectures presented at an International Vascular Biology Workshop held in London and chaired by Professor Dame Carol Black. The c- tents are complemented by some invited chapters, all written by world experts in areas of basic science and clinical medicine highly relevant to vascular biology and disease. We are particularly grateful to Professor Arshed Quyyumi, Professor of Medicine and Cardiology at Emory University, who with...
Winner of the Financial Times and Schroders Business Book of the Year 2023 A Behavioral Scientist Notable Book of 2023 A revolutionary guide that will transform your relationship with failure, from the pioneering researcher of psychological safety and award-winning Harvard Business School professor Amy Edmondson. We used to think of failure as the opposite of success. Now, we’re often torn between two “failure cultures”: one that says to avoid failure at all costs, the other that says fail fast, fail often. The trouble is that both approaches lack the crucial distinctions to help us separate good failure from bad. As a result, we miss the opportunity to fail well. After decades of awar...