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Non-Pharmacological Interventions
Non-pharmacological interventions (NPIs) have become essential solutions for better living, preventing disease, and self-care, in addition to biomedical treatments, and for increasing longevity without loss of quality of life. Over the past 20 years, these practices have gone from general diet and hygiene advice to targeted and personalized solutions for prevention, care optimization, and curative treatments. Selected empirically for centuries or recently with the help of technological innovations and epigenetic, interventional, and medico-economic studies, their development is growing and diversifying around the world. Today an NPI ecosystem is made up of a myriad of public and private acto...
Handbook of Anthropology in Business
The first comprehensive work on the burgeoning field of business anthropology, this innovative reference book, including more than 60 international scholar-practitioners, provides a foundation for the field for years to come.
Biosimilars
As many biological products face losing their patents in the next decade, the pharmaceutical industry needs an abbreviated regulatory pathway for approval of biosimilar drug products, which are cost-effective, follow-on/subsequent versions of the innovator’s biologic products. But scientific challenges remain due to the complexity of both the manufacturing process and the structures of biosimilar products. Written by a top biostatistics researcher, Biosimilars: Design and Analysis of Follow-on Biologics is the first book entirely devoted to the statistical design and analysis of biosimilarity and interchangeability of biosimilar products. It includes comparability tests of important quality attributes at critical stages of the manufacturing processes of biologic products. Connecting the pharmaceutical/biotechnology industry, government regulatory agencies, and academia, this state-of-the-art book focuses on the scientific factors and practical issues related to the design and analysis of biosimilar studies. It covers most of the statistical questions encountered in various study designs at different stages of research and development of biological products.
Applied Meta-Analysis with R
In biostatistical research and courses, practitioners and students often lack a thorough understanding of how to apply statistical methods to synthesize biomedical and clinical trial data. Filling this knowledge gap, Applied Meta-Analysis with R shows how to implement statistical meta-analysis methods to real data using R. Drawing on their extensive research and teaching experiences, the authors provide detailed, step-by-step explanations of the implementation of meta-analysis methods using R. Each chapter gives examples of real studies compiled from the literature. After presenting the data and necessary background for understanding the applications, various methods for analyzing meta-data ...
Crossing the Quality Chasm
Second in a series of publications from the Institute of Medicine's Quality of Health Care in America project Today's health care providers have more research findings and more technology available to them than ever before. Yet recent reports have raised serious doubts about the quality of health care in America. Crossing the Quality Chasm makes an urgent call for fundamental change to close the quality gap. This book recommends a sweeping redesign of the American health care system and provides overarching principles for specific direction for policymakers, health care leaders, clinicians, regulators, purchasers, and others. In this comprehensive volume the committee offers: A set of perfor...
Echocardiography
The book "Echocardiography - In Specific Diseases" brings together contributions from well- known researchers from around the world, some of them specialized in imaging science in their clinical orientation, but also representatives from academic medical centers. Each chapter is structured and written to be accessible to those with a basic knowledge of echocardiography but also to be stimulating and informative to experts and researchers in the field of echocardiography. This book is primarily aimed at cardiology fellows during their basic echocardiography rotation, fellows of internal medicine, radiology and emergency medicine, but also experts in echocardiography. During the past few decades technological advancements in echocardiography have been developing rapidly, leading to improved echocardiographic imaging using new techniques. The authors of this book tried to explain the role of echocardiography in several special pathologies, which the readers may find in different chapters of the book.
Adaptive Design Methods in Clinical Trials
With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clini
The Production of Knowledge
A wide-ranging discussion of factors that impede the cumulation of knowledge in the social sciences, including problems of transparency, replication, and reliability. Rather than focusing on individual studies or methods, this book examines how collective institutions and practices have (often unintended) impacts on the production of knowledge.
Statistical Analysis of Human Growth and Development
Statistical Analysis of Human Growth and Development is an accessible and practical guide to a wide range of basic and advanced statistical methods that are useful for studying human growth and development. Designed for nonstatisticians and statisticians new to the analysis of growth and development data, the book collects methods scattered throughout the literature and explains how to use them to solve common research problems. It also discusses how well a method addresses a specific scientific question and how to interpret and present the analytic results. Stata is used to implement the analyses, with Stata codes and macros for generating example data sets, a detrended Q-Q plot, and weight...
Optimal Design for Nonlinear Response Models
Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of
