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Gaba in Autism and Related Disorders
Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians. * Discusses the neuropathology of the GABA system in autism * Presents new findings on common genetic mechanisms in Rett syndrome, Angelman syndrome, and autism * Includes information on the shared genetic risk factors between autism and major mental disorders * Foreword by Eugene Roberts
New Perspectives of Central Nervous System Injury and Neuroprotection
Annotation Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Reviews written by experts in such a way thatprovides basic knowledge for beginners and advanced information for researchers and experts. New aspects of Neurodegenerative diseasessuch as;Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis are presented with thelatest therapeutic measures. Exacerbation of brain pathology in hypertension or diabetes is discussed for the first time.
International Review of Neurobiology
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
Mitochondrial Function and Dysfunction
Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease.* Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction* Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases* Includes outstanding list of contributing authors
Dietary Phenylalanine and Brain Function
This volume contains the manuscripts of the full papers and posters pre sented at the conference "Dietary Phenylalanine and Brain Function," which took place at the Park Hyatt Hotel, Washington, D.C., on May 8-10, 1987. The conference was organized by a committee that included Drs. Louis Elsas (Emory University, Atlanta), William Pardridge (UCLA), Timothy Maher (Massachusetts College of Pharmacy), Donald Schomer (Harvard), and Richard Wurtman (MIT). It was sponsored by the Center for Brain Sciences and Metabolism Charitable Trust, a foun dation which, during the past few years, had also organized seven other conferences related to interactions between circulating compounds (drugs, nutrients,...
Psychiatric Issues in Epilepsy
This volume is a pragmatic, comprehensive guide to evaluation and management of psychiatric problems in patients with epilepsy. The authors critically analyze recent findings on the relationship between seizures and psychiatric disorders and offer practical recommendations for diagnosis and treatment. Numerous case studies are included. This thoroughly updated edition includes new material on animal models of psychopathology in epilepsy, use of psychotropic drugs in epilepsy, use of antiepileptic drugs in psychiatry, neuroanatomic and neurobiologic bases of psychiatric disorders, neuropsychological evaluation in children with epilepsy, neuropsychological testing in epilepsy surgery candidates, and value and limitations of the forced normalization concept.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Models of Seizures and Epilepsy
An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic,...
Generalized Seizures: From Clinical Phenomenology to Underlying Systems and Networks
The present book is the fruit of a workshop, designed as a discussion forum, with the participation of experts from all over the world, to extensively review clinical, neurophysiological and fundamental research available data in order to generate new axes for research, clinical practice and care. The first section traces back to the definitions and concepts underlying the terms “generalized seizures and epilepsies”. Section II reviews human and animal data suggesting that the brainstem network plays an important role for tonic seizures generation. The third and fourth sections analyze recent knowledge on cortico-thalamic and basal ganglia networks in absence and myoclonic seizures, both in animal models and in humans. The fifth section compares the phenomenology of “Primary versus Secondary Tonico-clonic seizures”, including animal data, clinical expression in humans and genetics. Section VI goes back to the discussion “Cortical” versus “Centrencephalic” theories. The last two chapters thoroughly review the clinical applications of current knowledge, in terms of pharmacological approach and clinical care.
