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In recent years much enthusiasm and energy has been directed toward the development of human gene therapies, especially for inherited conditions and cancers. However, current gene transfer technology is limited in its transduction efficiency and ability to permanently and safely correct genomic defects. Thus the promise of gene therapy for these conditions is as yet unrealized. The progression of gene transfer technology will eventually surmount these limitations. Gene Therapy for Acute and Acquired Diseases includes selected examples of ongoing studies in molecular genetics that have the potential to evolve into human therapies for acute illnesses. These chapters are intended to highlight lesser known applications of gene therapy for acquired disorders. It is expected that human gene therapy trials for these conditions will be forthcoming in the near future, leading to previously unimaginable therapies. Thus, this first-ever book about gene therapy for acute and acquired diseases is intended to serve as a glimpse into the future.
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The Philosophy of Philip Kitcher offers an examination of the work of Philip Kitcher. It contains chapters written by leading scholars on Kitcher's work, as well as Kitcher's replies to these authors.
These two complete indexes rectify a number of shortcomings in the existing finding aids to Maryland wills. Altogether about 5,000 wills for St. Mary's County and 7,500 wills for Somerset County, many of them dated prior to 1800, are indexed.
In 1663, the Puritan missionary John Eliot, with the help of a Nipmuck convert whom the English called James Printer, produced the first Bible printed in North America. It was printed not in English but in Algonquian, making it one of the first books printed in a Native language. In this ambitious and multidisciplinary work, Phillip Round examines the relationship between Native Americans and printed books over a two-hundred-year period, uncovering the individual, communal, regional, and political contexts for Native peoples' use of the printed word. From the northeastern woodlands to the Great Plains, Round argues, alphabetic literacy and printed books mattered greatly in the emergent, tran...