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A 25-year Retrospective, Single Center Analysis of 343 WHO Grade II/III Glioma Patients: Implications for Grading and Temozolomide Therapy
Purpose: Classification and treatment of WHO grade II/III gliomas have dramatically changed. Implementing molecular markers into the WHO classification raised discussions about the significance of grading and clinical trials showed overall survival (OS) benefits for combined radiochemotherapy. As molecularly stratified treatment data outside clinical trials are scarce, we conducted this retrospective study. Methods: We identified 343 patients (1995-2015) with newly diagnosed WHO grade II/III gliomas and analyzed molecular markers, patient characteristics, symptoms, histology, treatment, time to treatment failure (TTF) and OS. Results: IDH-status was available for all patients (259 mutant, 84 IDH1-R132H-non-mutant). Molecular subclassification was possible in 173 tumors, resulting in diagnosis of 80 astrocytomas and 93 oligodendrogliomas. WHO grading remained significant for OS in astrocytomas/IDH1-R132H-non-mutant gliomas (p)
Immune Profile and Radiological Characteristics of Progressive Multifocal Leukoencephalopathy
Background and purpose: Progressive multifocal leukoencephalopathy (PML) constitutes a severe disease with increasing incidence, mostly in the context of immunosuppressive therapies. A detailed understanding of immune response in PML appears critical for the treatment strategy. The aim was a comprehensive immunoprofiling and radiological characterization of magnetic resonance imaging (MRI) defined PML variants. Methods: All biopsy-confirmed PML patients (n = 15) treated in our department between January 2004 and July 2019 were retrospectively analysed. Data from MRI, histology as well as detailed clinical and outcome data were collected. The MRI-defined variants of classical (cPML) and infla...
The Stranger (Patrik Hedstrom and Erica Falck, Book 4)
To avoid disappointment, please note this book was previously published under the title THE GALLOWS BIRD. Swedish crime sensation and No. 1 international bestseller, Camilla Lackberg’s fourth psychological thriller - for fans of Stieg Larsson and Jo Nesbo.
Musica Poetica: Musical-Rhetorical Figures in German Baroque Music
Musica Poetica provides an unprecedented examination of the development of Baroque musical thought. The initial chapters, which serve as an introduction to the concept and teachings of musical-rhetorical figures, explore Martin Luther’s theology of music, the development of the Baroque concept of musica poetica, the idea of the affections in German Baroque music, and that music’s use of the principles and devices of rhetoric. Dietrich Bartel then turns to more detailed considerations of the musical-rhetorical figures that were developed in Baroque treatises and publications. After brief biographical sketches of the major theorists, Bartel examines those theorists’ interpretation and cl...
Murder in Advent
The cathedral town of Litchester is more used to carols by candlelight during the festive period than flames and intrigue, but the proposed sale of its 1225 copy of the Magna Carta in order to raise funds turns out to have far-reaching consequences. Merchant banker Mark Treasure has been invited down to arbitrate the vicious disagreement between members of the cathedral chapter regarding the sale and finds himself dealing with more than he bargained for when the Dean's verger is discovered murdered, his body left to burn, along with the ecclesiastical library. As his investigation progresses and the evidence points to mayhem and skulduggery, he discovers that Litchester is a town full of sins and secrets rather than peace on earth.
Inequality of Opportunity
Eight papers, both theoretical and applied, on the concept of equality of opportunity which says that a society should guarantee its members equal access to advantage regardless of their circumstances, while holding them responsible for turning that access into actual advantage by the application of effort.
Architectural Invention in Renaissance Rome
Villa Madama, Raphael's late masterwork of architecture, landscape, and decoration for the Medici popes, is a paradigm of the Renaissance villa. The creation of this important, unfinished complex provides a remarkable case study for the nature of architectural invention. Drawing on little known poetry describing the villa while it was on the drawing board, as well as ground plans, letters, and antiquities once installed there, Yvonne Elet reveals the design process to have been a dynamic, collaborative effort involving humanists as well as architects. She explores design as a self-reflexive process, and the dialectic of text and architectural form, illuminating the relation of word and image in Renaissance architectural practice. Her revisionist account of architectural design as a process engaging different systems of knowledge, visual and verbal, has important implications for the relation of architecture and language, meaning in architecture, and the translation of idea into form.
Suffolk Surnames
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Teaching Mathematics in Seven Countries
Accompanying CD-ROM contains video clip examples.
