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A 25-year Retrospective, Single Center Analysis of 343 WHO Grade II/III Glioma Patients: Implications for Grading and Temozolomide Therapy
Purpose: Classification and treatment of WHO grade II/III gliomas have dramatically changed. Implementing molecular markers into the WHO classification raised discussions about the significance of grading and clinical trials showed overall survival (OS) benefits for combined radiochemotherapy. As molecularly stratified treatment data outside clinical trials are scarce, we conducted this retrospective study. Methods: We identified 343 patients (1995-2015) with newly diagnosed WHO grade II/III gliomas and analyzed molecular markers, patient characteristics, symptoms, histology, treatment, time to treatment failure (TTF) and OS. Results: IDH-status was available for all patients (259 mutant, 84 IDH1-R132H-non-mutant). Molecular subclassification was possible in 173 tumors, resulting in diagnosis of 80 astrocytomas and 93 oligodendrogliomas. WHO grading remained significant for OS in astrocytomas/IDH1-R132H-non-mutant gliomas (p)
Dictatorship as Experience
A decade after the collapse of communism, this volume presents a historical reflection on the perplexing nature of the East German dictatorship. In contrast to most political rhetoric, it seeks to establish a middle ground between totalitarianism theory, stressing the repressive features of the SED-regime, and apologetics of the socialist experiment, emphasizing the normality of daily lives. The book transcends the polarization of public debate by stressing the tensions and contradictions within the East German system that combined both aspects by using dictatorial means to achieve its emancipatory aims. By analyzing a range of political, social, cultural, and chronological topics, the contributors sketch a differentiated picture of the GDR which emphasizes both its repressive and its welfare features. The sixteen original essays, especially written for this volume by historians from both east and west Germany, represent the cutting edge of current research and suggest new theoretical perspectives. They explore political, social, and cultural mechanisms of control as well as analyze their limits and discuss the mixture of dynamism and stagnation that was typical of the GDR.
Kesselring's Last Battle
Revisits the war crimes trial of Albert Kesselring, commander-in-chief of German troops in Italy during Wold War II, who was sentenced to death for the killing of thousands of civilians in Italy. Reveals how the commutation of that death sentence was one of the earliest maneuverings in the nascent Cold War.
Perpetrators
"Monsters exist, but they are too few in number to be truly dangerous. More dangerous are the common men, the functionaries ready to believe and to act without asking questions." Primo Levi's words disclose a chilling truth: assigning blame to hideous political leaders, such as Hitler, Himmler, and Heydrich, is necessary but not sufficient to explain how the Holocaust could have happened. These leaders, in fact, relied on many thousands of ordinary men and women who made the Nazi machine work on a daily basis--members of the killing squads, guards accompanying the trains to the extermination camps, civilian employees of the SS, the drivers of gas trucks, and the personnel of death factories ...
Sprache und Recht
This volume presents a collection of contributions by linguists and lawyers on topical questions of the interconnections between language and law, and opens up a wide range of theoretical, methodological and practical approaches to aspects such as politics and the public domain, court proceedings, criminology, the editing of legislation, legal training, and the Europeanisation of law.
A Single Communal Faith?
How could the Right transform itself from a politics of the nobility to a fatally attractive option for people from all parts of society? How could the Nazis gain a good third of the votes in free elections and remain popular far into their rule? A number of studies from the 1960s have dealt with the issue, in particular the works by George Mosse and Fritz Stern. Their central arguments are still challenging, but a large number of more specific studies allow today for a much more complex argument, which also takes account of changes in our understanding of German history in general. This book shows that between 1800 and 1945 the fundamentalist desire for a single communal faith played a crucial role in the radicalization of Germany's political Right. A nationalist faith could gain wider appeal, because people were searching for a sense of identity and belonging, a mental map for the modern world and metaphysical security.
