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Development and Application of Herbal Medicine from Marine Origin
prodigiosin; marine viva; autophage; oral squamous cell carcinoma; Jaspine B; bile salts; intestinal permeability; bioavailability; metabolic instability; edible brown algae; protein enzymatic hydrolysate; ultrafiltration; ACE-inhibition; antioxidant properties; phlorotannins; peptide fractions; amino acids composition; marine functional foods; cardiovascular-health; Pachyclavularia; octocoral; cembrane; briarane; briarellin; secosterol; bioactivity; hepatic stellate cells; Pinnigorgia sp.; ROS; apoptosis; caspase-3; MAPK; sulfated galactan; 3T3 fibroblasts; green seaweed; radiation pneumonitis; lung fibrosis; fucoidan; cytokine; macrophage; neutrophil; neolignan; Lumnitzera racemosa; anti-angiogenesis; anti-inflammation; phomaketide A; lymphangiogenesis; lymphatic endothelial cells; vascular endothelial growth factor receptor-3
Drug Delivery Using Nanomaterials
After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful a...
A Milestone in Frontiers in Pharmacology: 1,000 Published Papers in the Section Experimental Pharmacology and Drug Discovery
Frontiers in Pharmacology was launched in 2010, with a number of sections which were eventually reorganized. The founding Field Chief Editor was Prof. Théophile Godfraind, an eminent scientist active in cardiovascular pharmacology, who pioneered the discovery of calcium antagonists. At that time he invited me to serve as Chief Editor for a section named “Analytical and Experimental Pharmacology”. Later on, our section enlarged and was re-named as “Experimental Pharmacology and Drug Discovery” to outline the translational potential of fundamental pharmacological research and theoretical analysis to the improvement of human health, through the invention of novel medicinal products. We are now entering the 10th year of editorial activity, which sees the publication of the 1,000th paper in our section. Such an achievement is very rewarding for us and our community, but it is even more remarkable when placed into the timeline of our development. In fact, in a 10-year frame we have significantly grown in quantity and quality, e.g. both in number of published papers and in scientific impact. [From a personal perspective by Salvatore Salomone, Specialty Chief Editor]
Terpenoids Against Human Diseases
This book highlights how terpenoids act as biological messengers and can be used as medicine against liver disease, neurodegenerative disease, cancer, infectious disease, cardiovascular disease, and inflammatory diseases. It emphasizes the metabolic engineering approach of terpenoids production and their toxicity.
Chemistry of Plant Natural Products
Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry.
Food and Drug Analysis
Aspects of food and drug analysis include exploring natural sources as healthy food, characterizing the molecular structures of bioactive principles, identifying novel drugs, assessing their affinity and specificity, and examining their bioactivities in vitro and in vivo. In addition to extensively applied chromatographic methods, nuclear magnetic resonance (NMR) spectroscopy is also used to screen for novel bioactive molecules. Various new sample preparation methods have been reported, especially for analysis in biological sample matrices. All these new analytical methods accelerate research and will make potential targets available in the near future.
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