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Schaechter's Mechanisms of Microbial Disease provides students with a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text is universally praised for "telling the story of a pathogen" in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. The table of contents is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula. Case studies with problem-solving questions give students insight into clinical applications of microbiology, which is ideal for problem-based learning.
Twenty-first century progress against infectious diseases is threatened by urbanization, population growth, war refugees, changing sexual standards, and a host of other factors that open doors to the transmission of deadly pathogens. Infectious Diseases in an Age of Change reports on major infectious diseases that are on the rise today because of changing conditions and identifies urgently needed public health measures. This volume looks at the range of factors that shape the epidemiology of infectious diseasesâ€"from government policies to economic trends to family practices. Describing clinical characteristics, transmission, and other aspects, the book addresses major infectious threats...
Now in full color, the Fourth Edition of this text gives students a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text facilitates learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. Case studies with problem-solving questions give students insight into clinical applications of microbiology. Each chapter ends with review and USMLE-style questions. For this edition, all schematic illustrations have been re-rendered in full color and new illustrations have been added. A new online site for students includes animations, USMLE-style questions, and all schematic illustrations and photographs from the text.
The chlamydiae are Gram-negative, obligate intracellular bacteria with a complex developmental cycle comprising a metabolically less-active, infectious stage, the elementary body (EB), and a metabolically more active stage, the reticulate body (RB). They are responsible for many acute and chronic diseases in humans and animals. In order to play a causative role in chronic diseases, chlamydiae would need to persist and to re-activate within infected cells/tissues for extended periods of time. Persistence in vitro is defined as viable but non-cultivable chlamydiae involving morphologically enlarged, aberrant, and nondividing RBs, termed aberrant bodies (AB). In vitro, alterations of the normal...
This volume provides a timely and authoritative account of Chlamydia and of the widespread, debilitating consequences of these microbial infections on humans. Sexually transmitted disease caused by C. trachomatis and the resulting infertility is of global importance. Trachoma itself is the world's major cause of preventable blindness affecting some 400 million people. C psittaci produces serious infection in a wide range of animals as well as in man. Growing awareness of the clinical importance of chlarnydial infection has been paralleled by an explosion in basic research on Chlamydia. Leading experts on Cblamydia were invited toreview these developments at the VIth International Congress on Human Chlamyclial Infections held in Sanderstead, England in June, 1986. This volume contains both reviews on topics ranging from antimicrobial chemotherapy to chlamydial genetics, and also research papers pointing to future developments.