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Genome Stability and Human Diseases
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific ge...
Transcriptome Profiling
Transcriptome Profiling: Progress and Prospects assists readers in assessing and interpreting a large number of genes, up to and including an entire genome. It provides key insights into the latest tools and techniques used in transcriptomics and its relevant topics which can reveal a global snapshot of the complete RNA component of a cell at a given time. This snapshot, in turn, enables the distinction between different cell types, different disease states, and different time points during development. Transcriptome analysis has been a key area of biological inquiry for decades. The next-generation sequencing technologies have revolutionized transcriptomics by providing opportunities for mu...
Understanding the Molecular Mechanisms of Plant Responses to Abiotic Stress
Plant responses to environmental stress are governed by complex molecular and biochemical signal transduction processes, which act in coordination to determine tolerance or sensitivity at the whole plant level. Upon exposure to abiotic stress, plants express a sophisticated coordinated response to reprogram interconnected defense networks and metabolic pathways, by alterations in the transcription, translation, and post-translational modification of defense-related genes and proteins. Traditionally, physiological and phenotypic responses were the major ones to be collected in plant stress biology. However, modern studies include the identification of key genes that influence stress tolerance...
