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Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
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Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state. This acclaimed serial features reviews written by experts in the area and is an indispensable reference for advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.
A definitive guide to veterans from Blair County, Pennsylvania who served in: Revolutionary War; War of 1812; Mexican War; Civil War; Spanish American War; and, World War 1. Many records include addresses, dates of birth and death, burial places and other information. Historical data on wars and the local area is also included.
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Learn to create and use simulation models—the most reliable and cost-effective tools for predicting real-world results! The Handbook of Processes and Modeling in the Soil-Plant System is the first book to present a holistic view of the processes within the soil-plant-atmosphere continuum. Unlike other publications, which tend to be more specialized, this book covers nearly all of the processes in the soil-plant system, including the fundamental processes of soil formation, degradation, and the dynamics of water and matter. It also illustrates how simulation modeling can be used to understand and forecast multiple interactions among various processes and predict their environmental impact. ...