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This book is the proceedings of the Falk Workshop on `Bile Acids in Hepatobiliary Disease', which took place at the Royal Society of Medicine (RSM) in London, UK, on 29-30 March 1999, and was held in association with the Section of Measurement in Medicine at the RSM. The main interest in bile acid therapy has been recently in cholestatic liver disease. The proceedings of the workshop not only discusses this, but moves on to examine its possible use in alcoholic liver disease, and moves back to re-examine its role in biliary disease. Leading world experts attempt to define its mechanism of action, and the current role of other non-surgical treatments in biliary disease. The physiology and pathogenesis of cholestatic and alcoholic liver disease and cholesterol gallstone disease is also examined.
Bile acids occupy a central position in in the absorption, excretion and metab olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage ment of these diseases is increasingly based on an understanding of the physicochemical ...
This book explores the industrial use of secure, permanent storage technologies for carbon dioxide (CO2), especially geological CO2 storage. Readers are invited to discover how this greenhouse gas could be spared from permanent release into the atmosphere through storage in deep rock formations. Themes explored here include CO2 reservoir management, caprock formation, bio-chemical processes and fluid migration. Particular attention is given to groundwater protection, the improvement of sensor technology, borehole seals and cement quality. A collaborative work by scientists and industrial partners, this volume presents original research, it investigates several aspects of innovative technolog...
The nonsurgical management of gallstone disease has drawn widespread clinical interest during the last decade as ultrasound surveys have indicated that cholelithiasis is predominantly an asymptomatic condition and much more prevalent than previously thought. This book presents an overwiew of the pathologic and pathobiochemical principles of gallstone formation and the consequences for clinical therapeutic regimens. New therapeutic applications of HMG-CoA-reductase inhibitors and nonsteroidal anti-inflammatory drugs are also critically reviewed. Finally, for the interested reader an evaluation of prophylactic treatment against stone recurrence after successful conservative treatment and an appraisal of alternative management strategies supplement the information on the conservative treatment of gallstones.
This new edition is dedicated to the maintenance of a comprehensive approach to the practice of pediatric gastroenterology. The size and content of various sections have been modified and new chapters have been added. Specific sections deal with Physiology and Pathophysiology, Clinical Presentation of Disease, Clinical Manifestations and Management (discussing the Mouth and Esophagus, The Stomach and Duodenum, The Intestine, and The Pancreas), Diagnosis of Gastrointestinal Diseases, and Principles of Therapy. Each author, selected because of their particular expertise in the field, has provided an authoritative and comprehensive account of their topic. This volume's need-to-know information is supported by a varied selection of tables, illustrations, and photographs.
Includes abstracts of the proceedings of the Medical Research Society and also that Society's Annual Guest Lecture.