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Bile Acids in Health and Disease
Bile acids occupy a central position in in the absorption, excretion and metab olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage ment of these diseases is increasingly based on an understanding of the physicochemical ...
Bile Acids in Hepatobiliary Disease
This book is the proceedings of the Falk Workshop on `Bile Acids in Hepatobiliary Disease', which took place at the Royal Society of Medicine (RSM) in London, UK, on 29-30 March 1999, and was held in association with the Section of Measurement in Medicine at the RSM. The main interest in bile acid therapy has been recently in cholestatic liver disease. The proceedings of the workshop not only discusses this, but moves on to examine its possible use in alcoholic liver disease, and moves back to re-examine its role in biliary disease. Leading world experts attempt to define its mechanism of action, and the current role of other non-surgical treatments in biliary disease. The physiology and pathogenesis of cholestatic and alcoholic liver disease and cholesterol gallstone disease is also examined.
Geological Storage of CO2 – Long Term Security Aspects
This book explores the industrial use of secure, permanent storage technologies for carbon dioxide (CO2), especially geological CO2 storage. Readers are invited to discover how this greenhouse gas could be spared from permanent release into the atmosphere through storage in deep rock formations. Themes explored here include CO2 reservoir management, caprock formation, bio-chemical processes and fluid migration. Particular attention is given to groundwater protection, the improvement of sensor technology, borehole seals and cement quality. A collaborative work by scientists and industrial partners, this volume presents original research, it investigates several aspects of innovative technolog...
Liver Disease in Children
This is the definitive book on pediatric liver disease, providing extensive, well-edited information that is not easily accessible or available in other textbooks. Read comprehensive information explaining the pathophysiology, clinical and laboratory diagnosis and clinical manifestations of liver disease. A must-have for those interested in this rapidly growing subspecialty in pediatrics. A Brandon-Hill recommended title.
Bone-Implant Interface in Orthopedic Surgery
Total joint arthroplasty is an effective surgical procedure for end-stage osteoarthritis of major joints with satisfactory long term clinical outcome. A large and growing number of arthroplasties are performed annually worldwide and a great number of orthopaedic surgeons are practicing arthroplasty surgery as their main surgical activity. The biological behavior of the bone-implant interface is crucial for the long term survival of the artificial joint. All factors which have a positive or negative effect on the interface are of great interest for those practicing arthroplasty surgery. Basic scientists and the industry are continuously searching for new implant fixation mechanisms and improv...
Gallstone Disease
The nonsurgical management of gallstone disease has drawn widespread clinical interest during the last decade as ultrasound surveys have indicated that cholelithiasis is predom inantly an asymptomatic condition and much more prevalent than previously thought. This book presents an overview of the pathophysiologic and pathobiochemical principles of gallstone formation and the consequences for clinical therapeutic regimens. New information concerning the balance between vesicular and micellar transport of choles terol, early cholesterol nucleation, and the influence of inhibiting and promoting com pounds for cholesterol nucleation as well as information concerning the effects of changes in gal...
Biochemical Pharmacology as an Approach to Gastrointestinal Disorders
The Gastrointestinal Section of the International Union of Pharmacology (IUPHAR) was established in 1994 in Montreal, Canada. The establishment of the GI Section recognizes the international progress of gastrointestinal pharmacology, including basic and human studies. The Gastrointestinal Section of IUPHAR organized the first symposium, Biochemical Pharmacology as an Approach to Gastrointestinal Diseases: from Basic Science to Clinical Perspectives, on 10-12 October, 1995, in Pécs, Hungary. The main topics were: Gastrointestinal secretory and excretory fuctions Gastrointestinal motility Biochemical-pharmacological mechanisms in neural and hormonal actions involved in GI functions Main normal and pathological biochemical mechanisms in GI functions GI mucosal injury and protection Molecular mechanisms of premalignant and malignant diseases in GI tract Use of isolated cells and cell cultures in bioochemical-pharmacological studies to approach GI diseases. The presented papers are published in this book.
Walker's Pediatric Gastrointestinal Disease
This new edition is dedicated to the maintenance of a comprehensive approach to the practice of pediatric gastroenterology. The size and content of various sections have been modified and new chapters have been added. Specific sections deal with Physiology and Pathophysiology, Clinical Presentation of Disease, Clinical Manifestations and Management (discussing the Mouth and Esophagus, The Stomach and Duodenum, The Intestine, and The Pancreas), Diagnosis of Gastrointestinal Diseases, and Principles of Therapy. Each author, selected because of their particular expertise in the field, has provided an authoritative and comprehensive account of their topic. This volume's need-to-know information is supported by a varied selection of tables, illustrations, and photographs.
