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The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity
Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research.
Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
Chronic Viral and Inflammatory Cardiomyopathy
The interconnectedness of genetics and susceptibility to disease, viral and non-viral inflammation, and the role of immunity and the development of autoimmunity is a fascinating and much discussed topic in cardiomyopathy. This publication constitutes the outcome of an ESRF meeting held together with the German Research Foundation. Clinical researchers, immunologists, virologists and molecular biologists provide the latest findings in their fields, advancing our understanding of what causes chronic viral and inflammatory cardiomyopathy, why it affects a subset of individuals while sparing the majority, how we can develop better therapies, and whether the disease can be prevented. Special emphasis is placed on the role of viruses in the aetiology and pathogenesis of cardiomyopathy. The editors are convinced that the broad spectrum covered by this state-of-the-art publication will be of exceptional value to its readers.
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Optimal dose individualization has become more important in improving clinical efficacy and safety. This is due in part to the variability in drug response. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. This book reviews innovative methods, tools and examples of rational drug development strategies, particularly for novel oncological agents.
PET Chemistry
Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for sp...
Chemical Genomics
Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
Progress in Immunology Vol. VIII
At this congress there were again numereous reports of progress in immunology. The new technologies are continuing to have an immense impact: gene isolation, mutation, transfection and expression, protein structure andpeptide synthesis, cell cloning, hybridization and monoclonal antibodies, CD serology, SCID and transgenic mice, modern immunomodulation and vaccines. A trmendous mass of data has accumulated over the last years. The reports are up-to-date and outstanding,to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for the years to came, because it is a treasure trove of explorations, making it exciting reading. This progress presents outstanding contributions. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever.
Innovations in Health Service Delivery
As the largest expenditure category of the health systems in both industrialised and developing countries, hospital care provision has been the focus of reforms over recent decades. This publication reviews recent trends in hospital policy reforms and options around the world; and includes case studies which offer insights into lessons learned. Issues considered include: differences in income levels, cultural settings and market environments; organisational changes such as increased management autonomy and privatisation; the need for parallel reforms and effective evaluation mechanisms.
Cell Biology
As the techniques of modern molecular biology continue to revolutionize experimental design in cell biology, mathematical modeling and analysis become increasingly necessary and feasible. The papers in this collection expand on invited lectures presented at the Symposium on Some Mathematical Questions in Biology: Cell Biology, held in November 1992 in Denver, Colorado. The work reviewed in the papers demonstrates the power of combining mathematics and experiment to study a number of cell processes, including: protein transport in nerve axons, formation of transport vesicles at the Golgi, molecular motion in cell membranes, cell adhesion, T lymphocyte activation, and cellular responses to receptor aggregation. The volume is an important contribution to the literature, as it introduces mathematicians to a growing application area and cell biologists to new tools and results. The individual articles can be used as readings in a course on mathematical modeling.
The Bass Handbook of Leadership
For thirty-three years and through three editions, Bass & Stogdill's Handbook of Leadership has been the indispensable bible for every serious student of leadership. Since the third edition came out in 1990, the field of leadership has expanded by an order of magnitude. This completely revised and updated fourth edition reflects the growth and changes in the study of leadership over the past seventeen years, with new chapters on transformational leadership, ethics, presidential leadership, and executive leadership. Throughout the Handbook, the contributions from cognitive social psychology and the social, political, communications, and administrative sciences have been expanded. As in the th...
