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It is by no means a revelation that proteins are not uniformly distributed throughout the cell. As a result, the idea that protein molecules, because of the specificity with which they can engage in interactions with other proteins, may be aimed—via these interactions—at a restricted target, is a fundamental one in contemporary molecular life sciences. The target may be variously c- ceived as a specific molecule, a group of molecules, a structure, or a more generic type of intracellular environment. Because the concept of protein targeting is intuitive rather than expl- itly defined, it has been variously used by different groups of researchers in cell biology, biochemistry, and molecular biology. For those working in the field of intracellular signaling, an influential introduction to the topic was the seminal article by Hubbard & Cohen (TIBS [1993] 18, 172–177), which was based on the work of Cohen’s laboratory on protein phosphatases. Sub- quently, the ideas that they discussed have been further developed and extended by many workers to other key intermediaries in intracellular sign- ing, including protein kinases and a great variety of modulator and adaptor proteins.
Using this award-winning 2-book set you can learn to sense, see, and heal auras. By reading the books and using the reference guide, you can tune into everything your auras can tell you about your past lives, as well as what others are thinking or feeling.
This text provides a masterful and systematic treatment of all the basic analytic and geometric aspects of Bergman's classic theory of the kernel and its invariance properties. These include calculation, invariance properties, boundary asymptotics, and asymptotic expansion of the Bergman kernel and metric. Moreover, it presents a unique compendium of results with applications to function theory, geometry, partial differential equations, and interpretations in the language of functional analysis, with emphasis on the several complex variables context. Several of these topics appear here for the first time in book form. Each chapter includes illustrative examples and a collection of exercises ...
Examines the social, political, economic, and military history of New Bedford, Massachusetts, in the nineteenth century, with a focus on the Civil War homefront, 1861-1865, and on the city's black community, soldiers, and veterans.