Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
The regulated secretory pathway in neuroendocrine cells
The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides.
Handbook of Biologically Active Peptides
Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides pres...
Neurosteroids
Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration did not affect the concentration of pregnenolone, dehydroepiandrosterone and their sulfate esters in the rat brain. These seminal observations led to the concept that the brain, in very much the same way as the adrenal cortex, testis, ovary and placenta, was capable of synthesizing steroids. These brain born steroids, called neurosteroids, have been found to exert a vast array of biological activities. A number of steroidogenic enzymes have now been identified in the central nervous system by immunohistochemistry and in situ hybridization, and the neuronal and hormonal mechanisms regulating the biosynthesis of neurosteroids have been partially elucidated. The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.
From Sex Differences in Neuroscience to a Neuroscience of Sex Differences: New Directions and Perspectives
This research topic aims to integrate scattered findings on sex differences in neuroscience into a broader theory of how the human brain is shaped by sex and sex hormones in order to cause the great variety of sex differences that are commonly observed. It can be assumed that these differences didn’t occur arbitrarily, but that they rather determined and still determine evolutionary success of individuals and were shaped by the processes of natural and in particular sexual selection. Therefore, sex differences are not negligible and sex difference research cannot be discriminating against one sex or the other. In fact a better understanding of the underlying causes of sex differences has g...
Trends in Comparative Endocrinology and Neurobiology
The comparative approach takes advantage of the biological diversity to select the most appropriate model organism to tackle a scientific question. Comparisons between the endocrine and nervous systems accross species have yielded major breakthroughs in endocrinology and neurobiology. For instance: a number of mammalian peptide hormones and neuropeptides have been originally identified in fish or amphibians; studies conducted in a sea slug founded the cellular and molecular basis of learning and memory; observations of neurogenesis in the forebrain of songbirds led to the discovery of adult neurogenesis in the mammalian brain. These examples illustrate the remarkable contribution of the comparative approach for the advancement of neuroendocrinological concepts. The present e-book is a unique collection of research articles and reviews that provide a representative overview of the latest developments in comparative endocrinology and neurobiology.
Neuropeptide GPCRs in neuroendocrinology
The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
Trends in Regulatory Peptides
Regulatory peptides represent the most diverse and versatile family of messenger molecules. They are produced by all living organisms from bacteria to mammals. They are involved in a wide variety of biological functions. Biologically active peptides and their receptors thus constitute an unlimited source of inspiration for the development of innovative drugs and cosmetics. The present eBook is a unique collection of research articles and reviews that provide a representative examplification of the latest progress in regulatory peptide research.
Elecciones en Puerto Rico -- Tomo II (1952-1964)
Este libro cubre las elecciones de 1952 al 1964, desde el dominio maximo del PPD, en 1952, hasta el primer relevo de gobernadores, aunque del mismo partido, en 1964. Cubre el ascenso del movimiento Estadista y la caida del movimiento Independentista. This book covers the elections held in Puerto Rico between 1952 and 1964. That period saw the highest point in the dominance by the Popular Party; and it also saw the fall and rebirth of the pro-Statehood movement (from 12.87%% in '52 to 34.8%% in '64), coupled with the rise and fall of the pro-Independence movement (from 18.98%% in '52 to 2.81%% in '64).
