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"Education, arts and social sciences, natural and technical sciences in the United States and Canada".
Target discovery is a field that has existed for several years but is so vibrant today because of the recent progress in our understanding of the molecular mechanisms of many human diseases and the technical advances in target identification and validation. More sophisticated gene profiling technologies, such as DNA microarrays and serial analysis of gene expression, permit rapid identification of lead targets. Moreover, analysis of gene networks in living organisms allows the identification of target genes that operate in defined physiological pathways. With the sequencing of several genomes completed and the rapidly growing gene expression databases, there is now greater impetus than ever ...
This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for ra...
To Julie Metz, her mother, Eve, was the quintessential New Yorker. It was difficult to imagine her living anywhere else except the Upper West Side of Manhattan. In truth, Eve had endured a harrowing childhood in Nazi-occupied Vienna, though she rarely spoke about it. Yet after her passing, Julie discovered a keepsake box filled with farewell notes from friends and relatives addressed to a ten-year-old girl named Eva, her mother. This was the first clue to the secret pain that Julie's mother had carried as an immigrant, and it shed light on a family that had to rely on its own perseverance to escape the xenophobia that threatened their survival. A beautiful blend of personal memoir and family history, Metz shows how one woman's search for her mother's lost childhood offers valuable lessons about the sacrifices people make to save their families during some of the darkest times in history.
Focusing on the key essentials you need to know, Axial Spondyloarthritis provides a quick, expert overview of axSpA from a clinical perspective. This concise resource by Drs. Philip Mease and Muhammad Khan presents practical recommendations and guidelines for the diagnosis, management, and treatment of spondyloarthritis impacting the axial skeleton alongside an overview of epidemiology, special populations, and patient education. - Discusses key information on genetic factors and disease biomarkers. - Presents an overview of clinical features, classification criteria, and imaging to aid in diagnosis. - Covers management and treatment guidelines, including non-pharmacologic management and the use of biologics. - Consolidates essential information on this timely topic into a single, convenient resource.
This comprehensive reference provides essential clinical information for planning and performing the full spectrum of cervical spine surgeries. Here, in one convenient volume, you'll receive expert, step-by-step guidance in both open and minimally invasive procedures, as well as instruction in relevant anatomy, instrumentation, and underlying principles. An Invaluable Resource Divided into five parts, the book begins with basic considerations and includes chapters on anatomy, biomechanics, minimally invasive versus open surgery: choosing the best approach, and image-guided spinal navigation for cervical techniques. Part II focuses on arthoplasty techniques and includes chapters on patient se...
Hormonal treatment of malignant diseases has been used for quite some years now, and progress in this field is still being made at a steady pace. The detection of new endocrine feed back loops and the availability of new classes of hormonal agents made hormonal intervention with predictable outcome possible. Besides the intellectual challenge of modulating the hormone system, an important aspect of recent research on hormones and cancer is the reduction of treatment-related morbidity achieved with the new hormonal strategies. Thus, controlled intervention in the hypothalamic-gonadotropic axis is increasingly apt to replace surgical removal of the relevant glands, i. e. , the pituitary gland ...