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What It Takes
Before Game Change there was What It Takes, a ride along the 1988 campaign trail and “possibly the best [book] ever written about an American election” (NPR). Written by Pulitzer Prize–winning journalist and New York Times–bestselling author Richard Ben Cramer, What It Takes is “a perfect-pitch rendering of the emotions, the intensity, the anguish, and the emptiness of what may have been the last normal two-party campaign in American history” (Time). An up-close, in-depth look at six candidates—George H. W. “Poppy” Bush, Bob Dole, Joe Biden, Michael Dukakis, Richard Gephardt, and Gary Hart—this account of the 1988 US presidential campaign explores a unique moment in histo...
When Big Data Was Small
Richard D. Cramer has been doing baseball analytics for just about as long as anyone alive, even before the term "sabermetrics" existed. He started analyzing baseball statistics as a hobby in the mid-1960s, not long after graduating from Harvard and MIT. He was a research scientist for SmithKline and in his spare time used his work computer to test his theories about baseball statistics. One of his earliest discoveries was that clutch hitting--then one of the most sacred pieces of received wisdom in the game--didn't really exist. In When Big Data Was Small Cramer recounts his life and remarkable contributions to baseball knowledge. In 1971 Cramer learned about the Society for American Baseba...
Joe DiMaggio
This is the life story of Joe DiMaggio, including his first game with the New York Yankees in the 1930s, his marriage to Marilyn Monroe & his rise to hero status. Richard Ben Cramer tells of the ways in which fame can both build & destroy.
What Do You Think of Ted Williams Now?
Richard Ben Cramer, Pulitzer Prize winner and acclaimed biographer of Joe DiMaggio decodes baseball icon Ted Williams and finds not just a great player, but also a great man. When legendary Red Sox hitter Ted Williams died on July 5, 2002, newspapers reviewed the stats, compared him to other legends of the game, and declared him the greatest hitter who ever lived. In 1986, Richard Ben Cramer spent months on a profile of Ted Williams, and the result was the Esquire article that has been acclaimed ever since as one of the finest pieces of sports reporting ever written. Given special acknowledgment in The Best American Sportswriting of the Century and adapted for a coffee-table book called Ted Williams: The Seasons of the Kid, the original piece is now available in this special edition, with new material about Williams's later years. While his decades after Fenway Park were out of the spotlight -- the way Ted preferred it -- they were arguably his richest, as he loved and inspired his family, his fans, the players, and the game itself. This is a remembrance for the ages.
Advances in Medicinal Chemistry
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment ...
International News Reporting
A collection of essays by top international correspondants in print, broadcasting, and photojournalism, International News Reporting offers an introduction to journalism written by the people who have made the profession what it is today. Contributors identify the major areas of professional practice which students and young journalists need to know in order to work safely in, and understand fully, the field of international news gathering Looks at events from conflicts to humanitarian disasters Covers crucial topics such as how to report stories about the developing world, how to avoid stereotyping, the uses and abuses of blogging, and risk assessment for journalists in conflict zones
3D QSAR in Drug Design
Volumes 2 and 3 of the 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the highly successful first volume about four years ago. Volume 2 (Ligand-Protein Interactions and Molecular Similarity) divides into three sections dealing with Ligand-Protein Interactions, Quantum Chemical Models and Molecular Dynamics Simulations, and Pharmacophore Modelling and Molecular Similarity, respectively. Volume 3 (Recent Advances) is also divided into three sections, namely 3D QSAR Methodology: CoMFA and Related Approaches, Receptor Models and Other 3D QSAR Approaches, and 3D QSAR Applications. More than seventy distinguished scientists have contributed nearly forty reviews of their work and related research to these two volumes which are of outstanding quality and timeliness. These works present an up-to-date coverage of the latest developments in all fields of 3D QSAR.
High Throughput Screening
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.
Bob Dole
Cramer penetrates Bob Dole's legendary reserve to decipher the enigma of his character and the vicissitudes of his career. Dole loyally served four Republican presidents--including one who treated him shabbily and another whose policies he often questioned--and has survived Congress for 35 years. Bob Dole is an invaluable barometer not only to Dole himself, but to American politi cs as a whole.
