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PARP Inhibitors for Cancer Therapy
PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.
Negotiating Class in Youth Justice
This book examines how class shapes interactions between professionals, parents, and young people in the youth justice system, utilising a mix of contemporary social theory and a wealth of empirical material. It suggests ways to neutralise the effects of class on youth justice interventions in structurally unequal societies and argues for reform based on conceptions of negotiated justice, relational agency, and autonomy in dependence. The author develops a theoretical framework to explore how class is negotiated within youth justice, taking as its starting point the work of Bourdieu on habitus, Boltanski and Thévenot on the sociology of lay normativity, and Sayer’s work on moral understan...
Medical Image Computing and Computer Assisted Intervention – MICCAI 2022
The eight-volume set LNCS 13431, 13432, 13433, 13434, 13435, 13436, 13437, and 13438 constitutes the refereed proceedings of the 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022, which was held in Singapore in September 2022. The 574 revised full papers presented were carefully reviewed and selected from 1831 submissions in a double-blind review process. The papers are organized in the following topical sections: Part I: Brain development and atlases; DWI and tractography; functional brain networks; neuroimaging; heart and lung imaging; dermatology; Part II: Computational (integrative) pathology; computational anatomy and physiology; op...
Decoding the Enigma of 9/11
Decoding the Enigma of 9/11: False Flags, Foreign Wars, and Forbidden Truths Unravel the mysteries, challenge the narratives, and embark on a journey of truth with "Decoding the Enigma of 9/11: False Flags, Foreign Wars, and Forbidden Truths." This ground-breaking exploration of one of the most pivotal events in modern history invites you to question, analyse, and critically examine the official account of September 11, 2001. In this thought-provoking book, we delve into the complexities and controversies surrounding the 9/11 attacks. By meticulously examining the pretext, scrutinizing the key players, and unravelling the unanswered questions, we navigate through the web of information and m...
The Alcalde
As the magazine of the Texas Exes, The Alcalde has united alumni and friends of The University of Texas at Austin for nearly 100 years. The Alcalde serves as an intellectual crossroads where UT's luminaries - artists, engineers, executives, musicians, attorneys, journalists, lawmakers, and professors among them - meet bimonthly to exchange ideas. Its pages also offer a place for Texas Exes to swap stories and share memories of Austin and their alma mater. The magazine's unique name is Spanish for "mayor" or "chief magistrate"; the nickname of the governor who signed UT into existence was "The Old Alcalde."
ROSE and IVY JOURNAL
ROSE & IVY Journal introduces the ultimate gift guide to inspire your holiday season with gifts for the bon vivant for The Polished Woman, The Entertainer to The Groomed Gentleman.
