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Systemic Lupus Erythematosus, An Issue of Rheumatic Disease Clinics
This issue brings the rheumatologist on the current thinking on treatment of Systemic Lupus Erythematosus, with an eye to the future. Topics covered include B cell biology and related therapies; glutamate receptor biology and its clinical significance in neuropsychiatric SLE; platelet C4d and vascular complications; biomarkers in lupus nephritis; endothelial function and its implications for cardiovascular and renal disease in SLE; changing worldwide epidemiology of SLE and its relationship to environmental, ethnic, and other sociodemographic factors; work loss, disability, quality of life, and compliance in SLE; pediatric lupus; metabolic syndrome and related endocrine abnormalities; the significance of interferon and the consequences of anti-interferon in SLE; and cutaneous lupus and the CLASI instrument.
Current Topics in Complement
The Third Aegean Conferences Workshop on Complement-Associated Diseases, Animal Models, and Therapeutics convened to discuss progress in complement research as it pertains to human disease pathogenesis and therapeutics. The rapid pace of research and new experimental approaches allow an integrated view of the in vivo biology of the complement system. This book collects writings on the functions of complement, pathophysiology, protein structures, design of complement inhibitors, and complement assays discussed at the conference.
Handbook of Mucosal Immunology
Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae.The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physio...
Natural Protectants Against Natural Toxicants
This volume provides a broad review of natural toxicants and natural protectants in food as well as the results of recent research on specific problems. This monograph was developed from a two-day workshop held at Iowa State University. Both harmful and health-protective natural components of food are topics of increasing popular interest and scientific research.
Biologic Markers in Immunotoxicology
Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markersâ€"sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.
Moderately Proteinuric IgA Nephropathy in the Young
IgA nephropathy (IgAN) is one of the most common glomerular diseases world-wide. Its natural history is consistent with a clinical onset in the first decades of life. Clinical indicators of poor prognosis are proteinuria and hypertension. Angiotensin-converting enzyme-inhibitors (ACE-I) are a promising treatment, since angiotensin II playes a key role in glomerular hypertension and permselectivity and modulates mesangial and tubular cell functions.
Neurogenetics
The rapid identification and characterization of genes of neurological relevance holds great potential for offering insight into the diagnosis, management, and und- standing of the pathophysiologic mechanisms of neurological diseases. This volume in the Methods in Molecular BiologyTM series was conceived to highlight many of the contemporary methodological approaches utilized for the characterization of neu- logically relevant gene mutations and their protein products. Although an emphasis has been placed upon descriptions of methodologies with a defined clinical utility, it is hoped that Neurogenetics: Methods and Protocols will appeal not only to clinical laboratory diagnosticians, but als...
Peritoneal Dialysis Today
Peritoneal dialysis (PD) is an invaluable tool in the treatment of patients with end-stage renal disease, which does not preclude a renal transplant, but incurs lower costs than other treatment options and represents an alternative when the vascular access is not feasible. Moreover, PD can be integrated in the armamentarium of different therapies and constitutes an important option when logistical or organizational problems are present. The publication on hand gives an account of the most recent studies on PD outcome and adequacy, exploring how different fluids, schedules and techniques may help to determine the most tolerated and effective dialysis for each patient. Novel systems including continuous flow PD are probing new limits of efficiency and performance. Biocompatibility and adequate correction of anemia are also among the issues discussed in this book, giving the reader the opportunity to refresh or expand his knowledge in the field. This publication definitely deserves a place on the desk of those who are engaged in the day-by-day activity of PD.
