You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Viral Gene Techniques is a practical laboratory guide to current techniques of molecular biology and genetics. The volume is concerned with methods for the analysis of viral genes and chromosomes: DNA viruses and RNA viruses including HIV are discussed.* Methods presented for ease of use and reasdy adaptation to new systems* Detailed experimental protocols included for:* Viral vectors - construction and use of DNA virus vectors (adenovirus, adeno-associated virus, vaccinia virus, Epstein - Barr virus)* DNA viruses - virus/host interactions, viral chromosomes , transcription regulation (viruses discussed include herpes simplex, hepatitis B, SV40, JC, Epstein-Barr, adenovirus)* Human Immunodeficiency Virus / retroviruses -quantitation of HIV-1 virus stock and RNA, retrovirus reverse transcription / integration, retrovirus-mediated cell fusion, use as cell lineage markers* RNA viruses - RNA virus assembly, analysis of RNA genomes, assays for RNA-binding proteins (viruses discussed include poliovirus, influenza virus, hepatitis delta virus)
First multi-year cumulation covers six years: 1965-70.
Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.
More than 40 years after the discovery of the nucleosome as the fun- mental unit of chromatin, the multifaceted problem of how variations in ch- matin structure affect the activity of the eukaryotic genome has not been solved. However, during the past few years research on chromatin structure and fu- tion has gained considerable momentum, and impressive progress has been made at the level of concept development as well as filling in crucial detail. The structure of the nucleosome has been visualized at unprecedented reso- tion. Powerful multisubunit enzymes have been identified that alter histone/ DNA interactions in ways that expose regulatory sequences to factors initi- ing and regulating ...
This book represents the proceedings of the NATO Advanced Study Institute held in Santa Flavia, Sicily from the 20 - 29th June, 1977. In addition to the review talks given by the Lecturers at the Institute it proved feasible for other topics to be splendidly reviewed. This has led to a much wider subject coverage than would otherwise have been possible. The discussion sessions which followed these review talks were extremely valuable and almost all the participants played an active role. Essentially all of the verbal contributions presented at this ASI were subsequently put into written format, which is why these proceedings are so extensive. ~hey do, however, provide an up-to-date summary o...
The third volume of the book series, The Crisis of Bourgeois Ideology, and the Doctrine of the Mode of Thinking, deals with the crisis of bourgeois natural science. Natural scientists generally are held in high esteem in bourgeois society because they are seemingly apolitical, unimpeachable, and committed solely to social progress. With the advance of positivism and pragmatism, however, the natural sciences lost much of their scientificity and have gotten into a crisis. This polemic is intended to revive materialistically based free thinking in the working class. Unless it frees itself from the shackles of idealism and metaphysics, humanity will not be able to utilize the achievements of the modern natural sciences for social progress. Thus, this book is also a must for every scientist with a critical mind. It serves the purpose of helping scientific socialism and its dialectical-materialist method gain new esteem.
1 - Chromosome Replication in Procaryotes.- Enzymatic Aspects of Chromosome Replication in E. coli.- Escherichia coli DNA Polymerase II and III.- Initiation of DNA Synthesis.- In vitro Replication of DNA.- The Role of ATP in Chromosome Replication Studied in Toluenized Escherichia coli.- Membrane Protein Components and DNA Synthesis in Escherichia coli.- A Possible Common Role for DNA Polymerase I and Exonuclease V in Escherichia coli.- The Joining of DNA Duplexes at Their Base-Paired Ends.- The Attachment of the Bacterial Chromosome to the Cell Membrane.- DNA Replication in Bacteriophage and.
Designed as an upper-level textbook and a reference for researchers, this important book concentrates on central concepts of the bacterial lifestyle. Taking a refreshingly new approach, it present an integrated view of the prokaryotic cell as an organism and as a member of an interacting population. Beginning with a description of cellular structures, the text proceeds through metabolic pathways and metabolic reactions to the genes and regulatory mechanisms. At a higher level of complexity, a discussion of cell differentiation processes is followed by a description of the diversity of prokaryotes and their role in the biosphere. A closing section deals with man and microbes (ie, applied microbiology). The first text to adopt an integrated view of the prokaryotic cell as an organism and as a member of a population. Vividly illustrates the diversity of the prokaryotic world - nearly all the metabolic diversity in living organisms is found in microbes. New developments in applied microbiology highlighted. Extensive linking between related topics allows easy navigation through the book. Essential definitions and conclusions highlighted. Supplementary information in boxes.