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Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II
More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity ...
Metabolic Compartmentation and Neurotransmission
The first symposium on metabolic compartmentation in brain was held at the Rockefeller Foundation, Bellagio, Italy, July 11-16, 1971; the proceedings CR. Balazs and J. E. Cremer, editors, MacMillan) appeared in 1973. At the conclusion of the first symposium it was decided to assess in 2-3 years the progress in this rapidly developing area. This volume represents the proceedings of an Advanced Study Institute, made possible by a grant from the North Atlantic Treaty Organization, Scientific Affairs Division. Additional generous support by the Wellcome Trust allowed attendance by participants from non-NATO countries. S. Ber! D. D. Clarke D. Schneider xi Introduction The term metabolic compartme...
The Hepatobiliary System
A volume on the biliary system appeared in 1965, based on a symposium of the NATO Advanced Institute held in September, 1963, in Newcastle upon Tyne in England. It soon became an authorita tive text on the problems of the biliary tract and, for instance, the discussion on the biliary secretion of organic anions, organic cations and inorganic ions were classic references. The worn pages of the volume in many libraries, including my own, bespeak its usefulness over ten long years. The initiative and energy of the Director of the first Institute have to be admired, even more so since he was able to assemble a Second Institute in Aalborg, Denmark, in 1975. His wisdom is reflected in the selectio...
Meat Animals
Dramatic shortfalls in crop production in various regions of the world have led some people to question the relatively inefficient use of cereal grains for feeding meat animals instead of their direct use for human food. There is no doubt, however, that meat offers a nutritionally valuable, attractive and widely accepted food, the world demand for which increases daily. Thus it is not enough simply to condemn the consumption of meat as an irresponsible extravagance; rather it is preferable to examine how the demand for meat can be met most efficiently and effectively, which requires a fundamental enquiry into how meat is 'grown'. The importance of fat, for instance, both to the growing anima...
Viruses, Evolution and Cancer Basic Considerations
Viruses, Evolution and Cancer: Basic Considerations focuses on comparative biology and evolutionary aspects of DNA and RNA oncogenic viruses. Organized into seven parts, this book begins with a discussion on the host-cell-virus relationships. Some chapters follow that discuss the comparative aspects of DNA and RNA oncogenic viruses. This work also elucidates the effects of oncogenic viruses on cell surface metabolism. Other chapters explore the comparative viral oncology, comparative immunology of oncogenic viruses, and evolution of viruses. This book will be an invaluable material both to those concerned in the scientific and medical problems of cancer and will benefit all who are interested in virology and oncology.
Phloem Transport
Ten years ago, at the International Botanical Congress in Edinburgh, a group of us from various countries discussed the difficulty of pursuing academic problems in depth at such meetings. In particular, we were discouraged at the poverty of time for phloem transport. From long association, we were conscious of the extraordinary breadth of the problem, from developmental through anatomical, to biophysical and physiological. Only by a reasonable understanding of all these components could one hope to come to some kind of understanding. We decided to establish common plant material so that data would have a common source. Similarly, we resolved to exchange information by circulating pre-publica...
Genetic Manipulations with Plant Material
Mankind, throughout history, has strived to improve his food sources. By means of slow and empirical selections, it has been possible to greatly increase both quantity and quality of plant crops. This procedure has brought the most useful cereals to a state of refinement that seems to be difficult to further improve by the same methodology. Indeed, natural sexual mechanisms were always used to cross closely related sexually and genetically compatible organisms; the selection procedure consisted of isolating the most promi sing progenies. Obviously, by this way, plants could only share preexisting genetic pools. On the other hand, the last decade has seen drastic modifi cations of the experim...
National Library of Medicine Current Catalog
First multi-year cumulation covers six years: 1965-70.
Specificity in Plant Diseases
A NATO Advanced Study Institute on "Phytotoxins in Plant Diseases" was held in Pugnochiuso (Italy) in June 1970. It was concerned mainly with the chemistry and mode of action of substances toxic to higher plants which are produced by pathogenic bacteria and fungi. The role of such substances in specificity was consider ed but largely in relation to host-specific toxins. In 1973, in light of the success of the 1970 Institute, we decided to plan for another in 1975 and after discussion with col leagues during the Second International Congress of Plant Pathology, we selected "Specificity in Plant Diseases" as the theme for the 1975 Institute. Our chief reasons for the choice were that specifici...
