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Lucinda is chosen to be a live-in chef as a birthday present for Joe, a handsome bachelor and highly praised investor. According to his grandmother, the woman giving him the gift, Joe is gay. Lucy is ecstatic to hear this. After her family went bankrupt and her fiancé left her, she’s sick of love. But things take a sudden turn when Joe gives her a sweet but passionate kiss. At the touch of his lips, Lucinda is reminded of the most embarrassing night of her life, when she was forcibly kissed by the same man!
Since Efron's profound paper on the bootstrap, an enormous amount of effort has been spent on the development of bootstrap, jacknife, and other resampling methods. The primary goal of these computer-intensive methods has been to provide statistical tools that work in complex situations without imposing unrealistic or unverifiable assumptions about the data generating mechanism. This book sets out to lay some of the foundations for subsampling methodology and related methods.
This is a book of a series on interdisciplinary topics of the Biological and Mathematical Sciences. The chapters correspond to selected papers on special research themes, which were presented at BIOMAT 2012 International Symposium on Mathematical and Computational Biology, in Tempe, Arizona, USA, November 6-10. This book contains state-of-the art articles on special research topics on mathematical biology, biological physics and mathematical modeling of biosystems; comprehensive reviews on interdisciplinary areas written by prominent leaders of scientific research groups. The treatment is both pedagogical and advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners.
Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.