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This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume will concentrate on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging technologies and non-pharmacological approaches to cognitive enhancement.
Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.
Presents an overview of the cellular and molecular mechanisms underlying the development of cognitive impairment. This book integrates discoveries concerning dementia, such as mild cognitive impairment and Alzheimer's disease associated dementia, retardation syndromes, and psychiatric and neurological disorders related cognitive impairments.
Leading researchers address conceptual and technical issues in schizophrenia and suggest novel strategies for advancing research and treatment. Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last fifty years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this book, leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment. The contributors addre...
This is a major revision of a standard reference work for neuropsychologists, psychiatrists, and neurologists. About one-half of the book contains entirely new work by new contributors. New topics not covered in the previous editions include consideration of common sources of neurocognitive morbidity, such as multiple sclerosis, diabetes, and exposure to heavy metals; psychiatric and behavioral disorders associated wtih traumatic brain injury; neuropsychology in relation to everyday functioning; the effects of cognitive impairment on driving skills, and adherence to medical treatments. The Third Edition aims to reflect the enormous developments in neuropsychology in terms of research, clinic...
A comprehensive handbook covering current, controversial, and debated topics in psychiatric practice, aligned to the EPA Scientific Sections. All chapters been written by international experts active within their respective fields and they follow a structured template, covering updates relevant to clinical practice and research, current challenges, and future perspectives. This essential book features a wide range of topics in psychiatric research from child and adolescent psychiatry, epidemiology and social psychiatry to forensic psychiatry and neurodevelopmental disorders. It provides a unique global overview on different themes, from the recent dissemination in ordinary clinical practice of the ICD-11 to the innovations in addiction and consultation-liaison psychiatry. In addition, the book offers a multidisciplinary perspective on emerging hot topics including emergency psychiatry, ADHD in adulthood, and innovation in telemental health. An invaluable source of evidence-based information for trainees in psychiatry, psychiatrists, and mental health professionals.
This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia. The work on cognition in schizophrenia from the past 20 years is highlighted, and emphasis throughout the book is placed on utilizing the Research Domain Criterion framework. Thus, the book also covers animals work relevant to schizophrenia that assesses behaviors utilizing the same framework, enabling mechanistic studies and highlighting potential biomarkers of function. The book also includes important areas of research in the field of cognitive function in schizophrenia that have received less attention, such as cognitive side-effects of current treatments and olfactory-based cognition. Altogether, the book provides a translational perspective of the most-up-to-date research on cognition in schizophrenia to-date, but with identification of novel directions for research initiatives..