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Rare Neurodegenerative Disorders - New Insights
Neurodegenerative diseases share the common property of neuronal loss in the higher-order association and limbic cortices or the extrapyramidal and pyramidal motor systems. In addition, oligodendroglia, astrocytes, and microglia have been implicated in fundamental abnormalities of virtually every neurodegenerative disorder. The particular system affected, more importantly the distribution of the pathology, determines the clinical presentation. While the most common dementia and movement disorders, such as Alzheimer’s disease, Lewy body disease, and frontotemporal lobar degeneration with TDP-43 pathology, including amyotrophic lateral sclerosis, have been extensively studied, many less comm...
Cell-Cell Channels
he biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. TThis concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are n...
Molecular Mechanisms in Legionella Pathogenesis
Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
Biomotors and their Nanobiotechnology Applications
This book – a collection of reviews and research articles by the top academics in the field – provides a glimpse of the cutting-edge technology and research being carried out and shows how researchers are utilizing this knowledge to develop new areas of study and novel applications. It serves as a valuable resource while exploring the latest advances in virus particle assembly and demonstrating how the knowledge of fundamental processes has been used to advance bio-nanotechnology. Chapters detail biophysical approaches and biomotor research, discus the latest advances in DNA/RNA nanoparticle assembly and use, and introduce the use of DNA/RNA nanoparticles for drug delivery.
Agrobacterium: From Biology to Biotechnology
Agrobacterium is a plant pathogen which causes the “crown-gall” disease, a neoplastic growth that results from the transfer of a well-defined DNA segment (“transferred DNA”, or “T-DNA”) from the bacterial Ti (tumor-inducing) plasmid to the host cell, its integration into the host genome, and the expression of oncogenes contained on the T-DNA. The molecular machinery, needed for T-DNA generation and transport into the host cell and encoded by a series of chromosomal (chv) and Ti-plasmid virulence (vir) genes, has been the subject of numerous studies over the past several decades. Today, Agrobacterium is the tool of choice for plant genetic engineering with an ever expanding host range that includes many commercially important crops, flowers, and tree species. Furthermore, its recent application for the genetic transformation of non-plant species, from yeast to cultivated mushrooms and even to human cells, promises this bacterium a unique place in the future of biotechnological applications. The book is a comprehensive volume describing Agrobacterium's biology, interactions with host species, and uses for genetic engineering.
The Dynamic Bacterial Genome
The genetic information contained in DNA is not static, especially in bacterial DNA. It is capable of recombining with other DNA sequences and transferring to other bacteria. These processes allow bacteria to rapidly respond to their environment and are also important in production of disease and the spread of antibiotic resistance. This book is concerned with the mechanisms underlying these dynamic processes in bacterial DNA.
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Science
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