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This work is a collection of short reviews on membranes and transport. It portrays the field as a mosaic of bright little pieces, which are interesting in themselves but gain full signif icance when viewed as a whole. Traditional boundaries are set aside and biochemists, biophysicists, physiologists, and cell biologists enter into a natural discourse. The principal motivation of this work was to ease the problems of communication that arose from the explosive growth and interdisciplinary character of membrane research. In these volumes we hope to provide a readily available comprehensive source of critical information covering many of the exciting, recent developments on the structure, biosy...
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are act...
Reprint of the original, first published in 1866.