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Ovarian Cancers
This book provides an overview of the latest developments in the concepts and management of ovarian cancer. The new data presented throughout opens the way to radically different therapeutic approaches. Surgery remains the core of ovarian cancer treatment, but its ultimate goal and the standard surgical procedure have evolved, giving rise to the question of how to label expert centers for debulking surgery. Neo-adjuvant chemotherapy is becoming more popular and is also a new field for testing novel drug combinations. Over recent years, ovarian cancer management has embraced molecular biology. It is now more correct to talk about cancers of the ovary rather than ovarian cancer, since it is not a unique disease but several entities with different molecular drivers. The significant advances in drugs targeting the microenvironment or the tumor cell DNA repair mechanisms are presented in detail together with exciting future perspectives. All these advances would not have been possible without collaborative groups such as the GINECO group in France and their integration in wider clinical research networks at the European (ENGOT) and international (GCIG) level.
Ovarian Cancer in Elderly Patients
This practical book provides up-to-date information on the particular features of ovarian cancer in older women and the best management approach. The full range of relevant topics is covered. Guidance is provided on geriatric assessment, screening, pathology, diagnosis, and follow-up. The various treatment options are carefully explained, covering surgical approaches, chemotherapy as a first-line strategy, the use of anti-angiogenic agents, and treatment of relapse. The cognitive problems that may arise in elderly women during and after treatment of ovarian cancer are documented, with advice on response. Guidance is also provided on the design of clinical trials, and current directions in biological research are reviewed. This book will be of value to both practitioners and researchers with an interest in ovarian cancer and the elderly.
Disaster Narratives in Early Modern Naples
This volume deals with natural disasters in late medieval and early modern central and southern Italy. Contributions look at a range of catastrophic events such as eruptions of Mount Vesuvius, floods, earthquakes, and outbreaks of plague and epidemics. A major aim of this volume is to investigate the relationship between catastrophic events and different communication strategies that embraced politics, religion, propaganda, dissent, scholarship as well as collective responses from the lower segments of society. The contributors to this volume share a multidisciplinary approach to the study of natural disasters which draws on disciplines such as cultural and social history, anthropology, literary theory, and linguistics. Together with analyzing the prolific production of propagandistic material and literary sources issued in periods of acute crisis, the documentation on disasters studied in this volume also includes laws and emergency regulations, petitions and pleas to the authorities, scientific and medical treatises, manuscript and printed newsletters as well as diplomatic dispatches and correspondence.
Small Animal Oncology
Neoplasms are common in dogs and cats and it has been estimated that 50% of dogs and cats aged over 10 years die of neoplasia. The demand for treatment of pets with cancer is increasing and seems likely to do so for the foreseeable future as more animals become insured and their treatment costs are covered. The purpose of this book is to provide a basic clinical approach to the diagnosis and treatment of the more common tumours in dogs and cats for the practising veterinary surgeon, undergraduate student and veterinary nurse. It is not intended to be a comprehensive reference book, covering all aspects of veterinary oncology, since several such texts exist. Rather it seeks to provide a core ...
Nanotechnology for Cancer Therapy
While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance fo
Hereditary Breast and Ovarian Cancer
This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.
