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Fusion of Biological Membranes and Related Problems
Membrane fusion and targeting processes are tightly regulated and coordinated. Dozens of proteins, originating from both the cytoplasm and membranes are involved. The discovery of homologous proteins from yeast to neurons validates a unified view. Although much is known about the interfering proteins, the events occurring when two lipid bilayers actually fuse are less clear. It should be remembered that lipid bilayers behave like soap-bubbles fusing when meeting each other. In this respect interfering proteins should be considered as preventing undesirable and unnecessary fusion and eventually directing the biological membrane fusion process (when, where, how, and overcoming the activation energy). In this latest volume in the renowned Subcellular Biochemistry series, some aspects of fusion of biological membranes as well as related problems are presented. Although not complete, there is a lot of recent information including on virus-induced membrane fusion. The contributors of the chapters are all among the researchers who performed many of the pioneering studies in the field.
Applications of Group-Theoretical Methods in Hydrodynamics
It was long ago that group analysis of differential equations became a powerful tool for studying nonlinear equations and boundary value problems. This analysis was especially fruitful in application to the basic equations of mechanics and physics because the invariance principles are already involved in their derivation. It is in no way a coincidence that the equations of hydrodynamics served as the first object for applying the new ideas and methods of group analysis which were developed by 1. V. Ovsyannikov and his school. The authors rank themselves as disciples of the school. The present monograph deals mainly with group-theoretic classification of the equations of hydrodynamics in the ...
Mycobacteria and the Macrophage
The macrophage (or “big eater”) is often considered the first cell type to encounter the causative agent of Tuberculosis (TB), Mycobacterium tuberculosis, upon entry to the lung. Once inside the macrophage the tubercle bacillus can survive and even replicate where many other invading pathogens perish. Recent research suggests the bacilli adapts within this hostile environment, treating the macrophage like a Trojan horse. Indeed, cutting-edge techniques have revealed that the degree of bacterial heterogeneity and resistance to antibiotics changes within the macrophage. M. tuberculosis spends most of its life cycle within the macrophage and has adopted specific mechanisms to survive, egres...
Toll-like Receptors in Inflammation
A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.
Nuclear Factor кB
Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell...
Sinn:voll!?
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Sacre Petit Coquin
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Le Monde de Michel Tremblay
Vingt-cinq collaborateurs (G. David, S. Lépine, L. Mailhot, P. Popovic, etc.). Etudes de pièces, études du cycle romanesque, essais, biobibliographie, p. 447-448. Selon l'éditeur il s'agit de la "première exploration en profondeur de l'écriture" du prolifique écrivain montréalais. Une cinquantaine d'illustrations. Recommandé. [SDM].
Obit
Declan Burke fled Ireland forty years ago and never looked back. Now settled in New York, he thinks he’s put the old country behind him, until he reads the obituary of one Cathal Murphy. The obituary, he sees at once, is not about Murphy at all. It is a coded indictment of Burke’s own life. And an announcement of his impending death. Halifax lawyer Monty Collins investigates the obit with its allusions to Burke’s IRA past. Collins gets no help from Burke, who — good soldier to the end — keeps the silence of the grave. But Burke’s denial becomes harder to maintain following a burst of gunfire at a family wedding. The shooting brings another old soldier onto the field: Leo Killeen,...
