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Without a Manual
In 2009, after being diagnosed with Erdheim-Chester Disease, a rare, life-ending illness, author Sandy Trunzer began a blog, with the simple intention of keeping friends updated on her health. Over time, and with feedback from an ever-increasing number of readers, Without a Manual evolved into a wry and unflinching account of what it’s like to see your death looming just ahead…and keep on living anyway. Through battles with insurers who refused to finance medications for an illness so rare there was no real medical protocol, and while suffering ever-diminishing health, increasing pain, and a devastating personal betrayal, Sandy continued to maintain her blog. A deeply insightful account of approaching the end of life with grace, love and humour, it lights a beacon – illuminating the way ahead for the sick and able-bodied alike.
BRAF Targets in Melanoma
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which e...
The Collaborative Economy in Action: European Perspectives
The book titled The Collaborative Economy in Action: European Perspectives is one of the important outcomes of the COST Action CA16121, From Sharing to Caring: Examining the Socio-Technical Aspects of the Collaborative Economy (short name: Sharing and Caring; sharingandcaring.eu) that was active between March 2017 and September 2021. The Action was funded by the European Cooperation in Science and Technology - COST (www.cost.eu/actions/CA16121). The main objective of the COST Action Sharing and Caring is the development of a European network of researchers and practitioners interested in investigating the collaborative economy models, platforms, and their socio-technological implications. Th...
Current Management of Melanoma
In the last decade, the clinical management of melanoma has become more effective: basic clinical studies, randomized clinical trials, and new drugs have greatly improved the prognosis of patients, both in the initial and in the advanced stage of the disease. This book offers a wide and up-to-date overview of the multidisciplinary treatment of melanoma. Among the topics discussed, there are the role of sentinel lymph node biopsy and the radical dissection, following the results of international randomized clinical trials, in particular MSLT-II. The last chapters are focused on new medical treatments in adjuvant, neoadjuvant, and metastatic settings. The volume has been written for all the professionals involved in melanoma treatment, such as general surgeons, surgical oncologists, medical oncologists, dermatologists, radiotherapists, and nuclear medicine physicians.
Advances in Industrial and Environmental Microbiology
The development of civilization entails the need to find new technological solutions leading to products with new properties. Allies in these efforts are microorganisms that have developed skills to synthesize products with properties of interest to the industry, environmental remediation or water treatment. The evolution of the omics approaches brought new tools to explore the microbial diversity and microorganisms' potential. These new methodological approaches are readily used in both industrial and environmental microbiology. This Special Issue collects research papers as well as review articles addressing recent advances on applied and environmental microbiology. The review articles cri...
Methods for Meta-Analysis in Medical Research
Major text including chapters on the following: defining outcome measures; assessing heterogeneity; using fixed effects methods and random effects models for combining study estimates; publication bias.
