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Metabolic diseases such as type 2 diabetes mellitus (T2DM), obesity, non-alcoholic fatty liver disease (NAFLD), and cancer are among the most prevalent health problems worldwide. These diseases are characterized by altered metabolism and impaired energy homeostasis, leading to the development of chronic diseases. Medicines derived from plants and fungi including herbal extracts and isolated compounds, have been used for centuries to treat various ailments and have recently gained renewed attention as potential therapeutics for metabolic diseases. Pharmacological approaches are essential for developing such preparations to treat these diseases. Computational approaches can generate early-stage hypotheses about potential targets and mechanisms and can be one basis for assessing the pharmacological activity of an extract or a metabolite. Understanding the molecular mechanisms underlying metabolic diseases and the potential benefits of herbal medicines (incl. herbal medical products) can provide valuable insights into new therapeutic targets and treatment options.
This new book highlights some of the exciting research that has recently been done in the important and far-ranging field of biofilms and microbial agents. It discusses antimicrobial agents in relation to biofilm control and resistance. The book also introduces biofilm formation and mitigation strategies. It helps explores long-term solutions to the challenges imposed by biofilms.
Our body is a machine that we need to lubricate and maintain; otherwise, it can sustain problems without regular maintenance. It’s quite clear that the human body is one of nature’s greatest accomplishments. The simple things that we take for granted every day are simply part of the smooth operation of this worldwide wonder, while astonishing acts, equally physical and mental, are directly credited to the marvel of the human body. Whereas it can be damaged, the body’s resiliency, rejuvenation, and restoration powers are in themselves miracles. In doing extensive study and research relating to human tissues, it’s impossible not to feel the wonderment of the human body. It certainly fo...
Natural resources and associated biological diversity provide the basis of livelihood for human population, particularly in the rural areas and mountain regions across the globe. Asia is home to the world's highest mountain regions including the Himalayas, Karakorum and Hindukush. These regions are renowned around the globe because of their unique beauty, climate, and biocultural diversity. Because of geoclimatic conditions, the mountains of Asia are medicinal and food plant diversity hot spots. The indigenous communities residing in the valleys of these mountains have their own culture and traditions, and have a long history of interaction with the surrounding plant diversity. Local inhabit...
This edited book covers all aspects of omics approaches used for the varietal improvement of millets in changing climatic conditions. Millets are the collection of small-grained cereal grasses, that are grown for human carbohydrate needs. They are among the oldest crops, mainly divided into two groups – Major and small millets based on seed size. Small millets are earlier considered orphan crops, but recently due to their nutritional values, they are getting importance in cultivation. This book explores the genomics, transcriptomics, proteomics, metabolomics, bioinformatics, and other omics tools that are being widely used to get a clear understanding of mechanistic approaches taken by pla...
This book provides in-depth insights into the diversity of actinobacteria, their various medical aspects, and their biotechnological applications. It is aimed at graduate students and researchers working with actinobacteria who need to know about recent advances in their research fields. The book, which is divided into four sections, contains 13 chapters that review the most recent methods, discuss various applications of actinobacteria, introduce some interesting results, and explore future prospects for the topics covered.
There is continuing interest in natural products as sources of potentially new and exciting chemical compounds. This book brings together the knowledge, perspectives and research findings of a varied group of scientists on a wide range of topics, from microarrays, genetics and bioinformatics to yeast-based technologies and enzyme studies. Scientists and clinicians in life science research will find useful information on new research techniques and tools. For the agriculturist, there is interesting information on the potential and problems of natural-based pesticides. The cancer researcher will find several plant sources with potential anti-cancer and immunomodulating compounds, as well as a ...
The investment profession is in a state of crisis. The vast majority of equity fund managers are unable to beat the market over the long term, which has led to massive outflows from active funds to passive funds. Where should investors turn in search of a new approach? Pulak Prasad offers a philosophy of patient long-term investing based on an unexpected source: evolutionary biology. He draws key lessons from core Darwinian concepts, mixing vivid examples from the natural world with compelling stories of good and bad investing decisions—including his own. How can bumblebees’ survival strategies help us accept that we might miss out on Tesla? What does an experiment in breeding tame foxes...
Qaidu (1236-1301), one of the great rebels in the history of the Mongol Empire, was the grandson of Ogedei, the son Genghis Khan had chosen to be his heir. This boof recounts the dynastic convolutions and power struggle leading up to his rebellion and subsequent events.