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The Handbook of Biological Therapy
Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Ther...
Gene Therapy for Autoimmune and Inflammatory Diseases
In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not...
Measuring Immunity
Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. Measuring Immunity is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology.* Defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity* Assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques * Includes basic science foundations as well as the approaches currently applied
Gastrointestinal Anatomy and Physiology
Gastroenterologists require detailed knowledge regarding the anatomy of the GI system in order to understand the disturbances caused by diseases they diagnose and treat. Gastrointestinal Anatomy and Physiology will bring together the world’s leading names to present a comprehensive overview of the anatomical and physiological features of the gastrointestinal tract. Full colour and with excellent anatomical and clinical figures throughout, it will provide succinct, authoritative and didactic anatomic and physiologic information on all the key areas, including GI motility, hepatic structure, GI hormones, gastric secretion and absorption of nutrients. GI trainees will enjoy the self-assessment MCQs, written to the level they will encounter during their Board exams, and the seasoned gastroenterologist will value it as a handy reference book and refresher for re-certification exams
Biologics in Inflammatory Bowel Disease
SERIES OVERVIEW: The Oxford American Pocket Notes are a series of ultra-concise, small-format books for healthcare professionals on topics related to the diagnosis, treatment and management of various medical conditions. Each title typically features an outline of key points, guidelines and tools such as patient assessments and treatment algorithms, for a specific area of medical diagnosis and/or management. Highly practical in format, content and style, the Pocket Notes serve as a quick, easily accessible point-of-care reference for busy practitioners. In effect, they are miniature versions of the Oxford American Medical Library and Oxford American Handbooks in Medicine, capturing the key e...
Immunity and Tolerance
The 78th Symposium volume covers many aspects of the immune system including the genetics, biochemistry, molecular and cell biology, and developmental biology of immune responses. New approaches intended to harness the immune system to treat disease, particularly cancer, are also discussed. The volume's broad synthesis of the current knowledge about immunity and tolerance includes molecular mechanisms of B and T lymphocyte development from the single cell to the entire organism and from single genes to genomes. There is a focus on the development and function of innate cells, including myeloid cells, natural killer cells, and a more recently defined innate lymphoid cell that resembles a T ce...
