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Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control
Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”. This view has now changed quite dramatically thanks to the –omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this...
Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control
Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”. This view has now changed quite dramatically thanks to the –omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this...
Science, Medicine, and Aristocratic Lineage in Victorian Popular Fiction
Science, Medicine, and Lineage in Popular Fiction of the Long Nineteenth Century explores the dialogue between popular literature and medical and scientific discourse in terms of how they represent the highly visible an pathologized British aristocratic body. This books explores and complicates the two major portrayals of aristocrats in nineteenth-century literature: that of the medicalised, frail, debauched, and diseased aristocrat, and that of the heroic, active, beautiful ‘noble’, both of which are frequent and resonant in popular fiction of the long nineteenth century. Abigail Boucher argues that the concept of class in the long nineteenth century implicitly includes notions of blood...
Towards Effective Disease Control in Ghana: Research and Policy Implications
The Noguchi Memorial Institute for Medical Research (NMIMR) was established in 1979 as a semi autonomous Institution of the University of Ghana. In 2000 it became one of the six founding constituent institutions of the College of Health Sciences. Its original mandate, to research into infectious tropical diseases of public health importance in Ghana, has lately been expanded to include non-communicable diseases. The Institute since its inception has offered undergraduate and graduate research opportunities, and training to numerous students and scientists as well as specialized diagnostic services to support national health programmes. The varied papers presented in these two volumes show th...
Genetics and Evolution of Infectious Diseases
Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industria...
A Most Interesting Problem
Leading scholars take stock of Darwin's ideas about human evolution in the light of modern science In 1871, Charles Darwin published The Descent of Man, a companion to Origin of Species in which he attempted to explain human evolution, a topic he called "the highest and most interesting problem for the naturalist." A Most Interesting Problem brings together twelve world-class scholars and science communicators to investigate what Darwin got right—and what he got wrong—about the origin, history, and biological variation of humans. Edited by Jeremy DeSilva and with an introduction by acclaimed Darwin biographer Janet Browne, A Most Interesting Problem draws on the latest discoveries in fie...
Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism
Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
The Shapes of Epidemics and Global Disease
This volume investigates the multifaceted SHAPES (socio-historic, artistic, political, and ecological significance) of global disease. It challenges conventional views of infection and transmission by associating epidemics with ideologies and their accompanying institutions. It argues that the physical threat of epidemics is irrevocably linked to culture, economic resources, social class, and power. Epidemics involve both the infected and non-infected, affect the local and global, and they expose control and neglect. This book provides a radical collaborative approach, drawing contributors from closely related and vastly distant fields in the search for innovative ways to address human suffe...
Ecology in Action
Providing students with a solid understanding of core ecological concepts while explaining how ecologists raise and answer real-world questions, this second edition weaves together classic and cutting-edge case studies to bring the subject to life. It is fully updated throughout, including two chapters devoted to climate change ecology, along with extensive coverage of disease ecology, and has been designed specifically to equip students with the tools to analyze and interpret real data. Each chapter emphasizes the linkage between observations, ideas, questions, hypotheses, predictions, results, and conclusions. Additional summary sections describe the development and evolution of research programs in each of ecology's core areas, providing students with essential context. Integrated discussion questions, along with end-of-chapter questions, encourage active learning. These are supported by online resources including tutorials that teach students to use the R programming language for statistical analyses of data presented in the text.
The Guts of the Matter
This engaging interdisciplinary study integrates the deep histories of infectious intestinal disease transmission, the sanitation revolution, and biomedical interventions.
