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A collection of cutting-edge accounts of special topics from various fields of forensic pathology and death scene investigation. The authors offer critical insight into the medicolegal investigation of bodies found in water, the forensic aspects of the human immunodeficiency virus (HIV)-1 infection of the central nervous system, deaths in a head-down position, and forensic bitemark analysis. Additional chapters address taphonomic changes in human bodies during the early postmortem interval, arrhythmogenic ventricular dysplaisia that produces sudden death in young people, the postmortem diagnosis of death in anaphylaxis, and iatrogenici deaths. The forensic aspects of suicide, murder-suicide, and suicide trends in the United States are also discussed, along with the evaluation of fatal pulmonary thromboembolism and the use of radiology in medicolegal investigations.
In this new volume of the globally recognized Forensic Pathology Reviews, Dr. Michael Tsokos has gathered chapters from the top experts in the field to reveal both the applied and scientific areas of expertise along the broad spectrum of forensics studies. Volume 5 piques the mind as leading forensic pathologists from the United States and around the world offer advanced insight into death caused environmental conditions, trauma, neuropathology, natural causes, and ballistics. The authors of this volume further their exploration as they impart research related to identification, serial murder, histopathology, and age estimation. While unveiling unsurpassed and cutting-edge knowledge, Forensic Pathology Reviews, Volume 5 will also inspire emerging forensic scientists to immerse themselves in innovative research.
A collection of cutting-edge reviews of many of the key recent medical and legal advances in forensic science. These critical surveys concentrate on common pathological entities likely to be encountered in daily forensic routine, as well as on specific pathological conditions rarely seen in the autopsy room. Complementing rather than replacing the classic textbooks in forensic pathology, the authors explore new avenues for analyzing the pathology of burned bodies, traumatic brain injury, death by drug abuse, sudden cardiac death, sudden infant death and neonaticide, and fatalities resulting from kicking and trampling. Other areas of interest include accidental autoerotic deaths, hypothermia fatalities, injuries from resuscitation procedures, the interpretation of alcohol levels in different specimens, and the potential forensic differential diagnoses and interpretation of iliopsoas muscle hemorrhage in the light of autopsy.
Cancer, a global health crisis, is projected by WHO to cause 10 million deaths by 2020, with a mortality rate of one in six. This has spurred intensive research for innovative treatments. Cancer arises from genetic abnormalities triggering uncontrolled cell division, presenting distinct hallmarks. Both inherited and acquired mutations transform cell behavior, resulting in abnormal growth, reproduction, and death. Environmental toxins and spontaneous mutations contribute to genetic changes, while hereditary factors predispose some individuals. Despite rapid advancements in targeted treatments and immunotherapy, therapy resistance remains a formidable challenge due to the disease's heterogeneity. Understanding cancer biology is crucial for developing effective treatments. This book provides a comprehensive overview, covering basic cell biology, genetics, cancer development mechanisms, immune system involvement, diagnostic methods, treatment modalities, including emerging therapies, and challenges like drug resistance. Geared towards students and researchers in biology, medicine, and oncology, it offers vital insights into combating this complex disease.
First multi-year cumulation covers six years: 1965-70.
Many autoimmune diseases are induced by pathogenic autoantibodies, that bind to self-antigen expressed in cells and tissues, and induce disease by the recruitment of immune cells, activation of the classical complement pathway or induction of antigen cross-linking and endocytosis. These pathogenic mechanisms are, however, not available to antibodies of the IgG4 subclass, as these differ structurally from the other IgG subclasses, leaving them “immunologically inert”. In general, it is thought that IgG4 is part of an anti-inflammatory immune response to an overreactive pro-inflammatory response, e.g. in the context of helminth infection and allergy.
Publisher’s note: In this 2nd edition, the following article has been added: “Editorial: Involvement of Bioactive Peptides in the Control of Cell Survival, Proliferation and Plasticity in Physiological and Pathological Conditions”