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An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
lncRNAs (long non-coding RNAs) are the relatively longer (more than 200 nucleotides long) subtypes of ncRNAs (non-coding RNAs) i.e the RNAs that do not code for any proteins. However, even without themselves being translated, lncRNAs impact the cellular gene expressions and functions in ways that are just beginning to be explored. The metastasis of human cancers as well as acquired resistance against the administered therapeutics are two major factors responsible for the cancer-associated mortality.
This book constitutes the thoroughly refereed post-proceedings of the 7th China-Japan Conference on Discrete Geometry, Combinatorics and Graph Theory, CJCDGCGT 2005, held in Tianjin, China, as well as in Xi'an, China, in November 2005. The 30 revised full papers address all current issues in discrete algorithmic geometry, combinatorics and graph theory.
The two-volume set LNCS 7732 and 7733 constitutes the thoroughly refereed proceedings of the 19th International Conference on Multimedia Modeling, MMM 2012, held in Huangshan, China, in January 2013. The 30 revised regular papers, 46 special session papers, 20 poster session papers, and 15 demo session papers, and 6 video browser showdown were carefully reviewed and selected from numeroues submissions. The two volumes contain papers presented in the topical sections on multimedia annotation I and II, interactive and mobile multimedia, classification, recognition and tracking I and II, ranking in search, multimedia representation, multimedia systems, poster papers, special session papers, demo session papers, and video browser showdown.
This book constitutes the refereed proceedings of the 2021 International Conference on Business Intelligence and Information Technology (BIIT 2021) held in Harbin, China, during December 18–20, 2021. BIIT 2021 is organized by the School of Computer and Information Engineering, Harbin University of Commerce, and supported by Scientific Research Group in Egypt (SRGE), Egypt. The papers cover current research in electronic commerce technology and application, business intelligence and decision making, digital economy, accounting informatization, intelligent information processing, image processing and multimedia technology, signal detection and processing, communication engineering and technology, information security, automatic control technique, data mining, software development, and design, blockchain technology, big data technology, artificial intelligence technology.